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AXIN1 — WNT3A

Pathways - manually collected, often from reviews:

• NCI Pathway Database Canonical Wnt signaling pathway: WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2) → Axin1/GSK3 complex (AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Zeng et al., Nature 2005, Bilic et al., Science 2007, Zeng et al., Development 2008
  Evidence: assay, physical interaction
• NCI Pathway Database Canonical Wnt signaling pathway: WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Zeng et al., Nature 2005, Bilic et al., Science 2007, Zeng et al., Development 2008
  Evidence: assay, physical interaction
• NCI Pathway Database Canonical Wnt signaling pathway: Axin1/GSK3 complex (AXIN1-GSK3B_GSK3A) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Zeng et al., Nature 2005, Bilic et al., Science 2007, Zeng et al., Development 2008
  Evidence: assay, physical interaction
• NCI Pathway Database Canonical Wnt signaling pathway: beta catenin (CTNNB1) → WNT3A/LRP6/FZD5/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: APC (APC) → WNT3A/LRP6/FZD5/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1) → WNT3A/LRP6/FZD5 complex (WNT3A-LRP6-FZD5) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1) → WNT3A/LRP6/FZD5/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: WNT3A/LRP6/FZD5 complex (WNT3A-LRP6-FZD5) → WNT3A/LRP6/FZD5/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Degradation of beta catenin: CK1 epsilon-CK1 delta-CK1 alpha (CSNK1E/CSNK1A1/CSNK1D) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, activates)
  Kishida et al., Oncogene 1999, Kodama et al., J Biol Chem 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Orford et al., J Biol Chem 1997, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Degradation of beta catenin: WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2) → Axin1/APC//beta catenin complex (AXIN1-APC-CTNNB1) (modification, inhibits)
  Kishida et al., Oncogene 1999, Kodama et al., J Biol Chem 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Orford et al., J Biol Chem 1997, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Degradation of beta catenin: WNT3A/LRP6/FZD5 complex (WNT3A-LRP6-FZD5) → Axin1/APC//beta catenin complex (AXIN1-APC-CTNNB1) (modification, inhibits)
  Kishida et al., Oncogene 1999, Kodama et al., J Biol Chem 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Orford et al., J Biol Chem 1997, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Canonical Wnt signaling pathway: WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2) → Axin1/GSK3 complex (AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Piao et al., PloS one 2008, Yum et al., Biochem Biophys Res Commun 2009
  Evidence: assay, physical interaction
• NCI Pathway Database Canonical Wnt signaling pathway: WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Piao et al., PloS one 2008, Yum et al., Biochem Biophys Res Commun 2009
  Evidence: assay, physical interaction
• NCI Pathway Database Canonical Wnt signaling pathway: Axin1/GSK3 complex (AXIN1-GSK3B_GSK3A) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Piao et al., PloS one 2008, Yum et al., Biochem Biophys Res Commun 2009
  Evidence: assay, physical interaction
• NCI Pathway Database Canonical Wnt signaling pathway: beta catenin (CTNNB1) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: beta catenin (CTNNB1) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: APC (APC) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: APC (APC) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: WNT3A/LRP6/FZD5/DVL/Axin1/GSK3/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: CK1 gamma (CSNK1G1) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, activates)
  Davidson et al., Nature 2005, Zeng et al., Nature 2005, Zeng et al., Development 2008
  Evidence: assay, physical interaction
• NCI Pathway Database Canonical Wnt signaling pathway: CK1 gamma (CSNK1G1) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, activates)
  Zeng et al., Nature 2005, Piao et al., PloS one 2008, Yum et al., Biochem Biophys Res Commun 2009
  Evidence: assay, physical interaction
• NCI Pathway Database Canonical Wnt signaling pathway: WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2) → Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: APC (APC) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: beta catenin (CTNNB1) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• Reactome Reaction: AXIN1 → WNT3A (indirect_complex) Mao et al., Mol Cell 2001, Tamai et al., Mol Cell 2004, He et al., Development 2004, Davidson et al., Nature 2005, Zeng et al., Nature 2005, Yamamoto et al., Dev Cell 2006, Schwarz-Romond et al., Nature structural & molecular biology 2007, Bilic et al., Science 2007, Zeng et al., Development 2008, MacDonald et al., J Biol Chem 2008, Yamamoto et al., Dev Cell 2008
• Reactome Reaction: AXIN1 → WNT3A (reaction) Mao et al., Mol Cell 2001, Tamai et al., Mol Cell 2004, He et al., Development 2004, Zeng et al., Nature 2005, Schwarz-Romond et al., Nature structural & molecular biology 2007, Bilic et al., Science 2007, Zeng et al., Development 2008, MacDonald et al., J Biol Chem 2008

Text-mined interactions from Literome

Kishida et al., Oncogene 1999 : These results suggest that Axin forms a complex with GSK-3beta, beta-catenin, and APC, resulting in the stimulation of the degradation of beta-catenin and that Wnt-3a induces the dissociation of beta-catenin from the Axin complex and accumulates beta-catenin
Yamamoto et al., Dev Cell 2006 : Overall, our data suggest that Wnt-3a triggers the interaction of LRP6 with caveolin and promotes recruitment of Axin to LRP6 phosphorylated by glycogen synthase kinase-3beta and that caveolin thereby inhibits the binding of beta-catenin to Axin
Yokoyama et al., Journal of molecular signaling 2012 : These data demonstrate that Wnt3a activation of the canonical pathway requires specific phosphorylation events as well as Axin to assemble very large, Dvl3 based supermolecular complexes ; these complexes are a prerequisite to activation of Lef/Tcf-sensitive transcription
Yang et al., PloS one 2012 (Carcinoma, Hepatocellular...) : Knockdown of KLF8 using shRNA inhibits Wnt3a induced transcription of TOP flash report gene and expression of c-Myc, cyclin D1 and Axin1
Mao et al., Invest Ophthalmol Vis Sci 2012 (Wnt Signaling Pathway) : A TCF/LEF luciferase assay was used to study functional canonical Wnt signaling, which was confirmed further by WNT3a induced expression of a pathway target gene, AXIN2 , via quantitative PCR