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CTR9 — PLA2G4A

Text-mined interactions from Literome

Dessen et al., Cell 1999 : Cytosolic phospholipase A2 initiates the biosynthesis of prostaglandins, leukotrienes, and platelet activating factor (PAF) , mediators of the pathophysiology of asthma and arthritis
Urasaki et al., J Leukoc Biol 2001 : These findings suggest that IL-5 activates both cPLA2 and 5-LO but PAF activates only 5-LO
Si et al., Am J Physiol Gastrointest Liver Physiol 2008 (Adenocarcinoma...) : PAF significantly increased the phosphorylation of ERK1/2 MAPK, cPLA(2) , and STAT5 ... Using inhibitors, we demonstrated that PAF induced STAT5 phosphorylation depends on activation of ERK1/2 MAPK and cPLA(2), whereas PAF induced cPLA(2) phosphorylation was associated with activation of ERK1/2 MAPK
Ma et al., Am J Physiol Gastrointest Liver Physiol 2010 : The increase was reduced by the p38 MAP kinase ( p38 ) inhibitor SB203580, by the cytosolic phospholipase A2 ( cPLA(2) ) inhibitor AACOCF3, and by the lyso-PAF acetyltransferase inhibitor sanguinarin, indicating that capsaicin induced PAF production may be mediated by activation of cPLA(2) , p38, and lyso-PAF acetyltransferase
Makiyama et al., Eur J Pharmacol 2012 : Treatment with C2-DE-C1P did not modify phosphorylation of extracellular signal regulated kinase 1/2 and cPLA(2)a and increase of intracellular Ca ( 2+ ) level induced by PAF, but inhibited Ca ( 2+ ) - and PAF induced accumulation of cPLA(2)a in the Golgi complex ... Interestingly, C2-DE-C1P inhibited neither Ca ( 2+ ) - and PAF induced accumulation of C2 domain of cPLA(2)a in the Golgi complex nor binding of cPLA(2)a to C16-C1P
Bauldry et al., Biochim Biophys Acta 1996 : This study clearly shows that cPLA2 activation can provide precursors for both LTB4 and PAF, that maximum PAF and LTB4 formation occur under conditions that induced optimal cPLA2 activation, that a close coupling between LTB4 and PAF formation exists, and that, after substrate generation, no additional requirements are necessary for LTB4 and PAF generation in the permeabilized PMN system
Qiu et al., J Biol Chem 1998 : Unlike zymosan, which is a strong activator of mitogen activated protein kinase ( MAPK ), ATP and PAF were weak MAPK activators and induced only a partial and transient increase in cPLA2 phosphorylation ( gel shift )
Hirabayashi et al., Biochem Biophys Res Commun 1998 : Stimulation of platelet activating factor (PAF) receptor induces activation of extracellular signal regulated kinase ( ERK ) and cytosolic phospholipase A2 (cPLA2) and release of arachidonic acid in Chinese hamster ovary cells ... Pretreatment of cells with an MEK inhibitor, PD98059, had similar effects on PAF induced cPLA2 phosphorylation and arachidonic acid release