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EPAS1 — IGF1

Text-mined interactions from Literome

Akeno et al., Endocrinology 2002 : Pretreatment of the cells with LY294002 also greatly attenuated IGF-I induction of HIF-2alpha and blunted IGF-I induced VEGF promoter activity
Carroll et al., Cancer Res 2006 (Breast Neoplasms...) : To address this, we used small interfering RNA ( siRNA ) techniques to knockdown HIF-1alpha and/or HIF-2alpha expression in response to hypoxia, insulin-like growth factor (IGF)-I , or renal carcinoma cells expressing constitutively high basal levels of HIF-1alpha and/or HIF-2alpha due to loss of von Hippel-Lindau (VHL) function