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HSP90AA1 — SRC

Pathways - manually collected, often from reviews:

• NCI Pathway Database Class I PI3K signaling events: None → PDK1/Src/Hsp90 complex (PDPK1-SRC-HSP90AA1) (modification, activates)
  Park et al., EMBO J 1999*, Yang et al., J Biol Chem 2008*
  Evidence: mutant phenotype, physical interaction
• Reactome Reaction: HSP90AA1 → SRC (reaction) Schaller et al., Biochem J 2001, Le Boeuf et al., J Biol Chem 2004
• Reactome Reaction: HSP90AA1 → SRC (direct_complex) Le Boeuf et al., Mol Biol Cell 2006
• Reactome Reaction: HSP90AA1 → SRC (indirect_complex) Le Boeuf et al., J Biol Chem 2004
• WikiPathways Aryl Hydrocarbon Receptor Pathway: Complex of SRC-AIP-AHR-HSP90AA1-PTGES3 → AHR (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SRC — HSP90AA1 (physical association, affinity chromatography technology) Hutchison et al., J Biol Chem 1992*
• IRef Biogrid Interaction: SRC — HSP90AA1 (physical association, affinity chromatography technology) Tsutsumi et al., Proc Natl Acad Sci U S A 2012*
• IRef Dip Interaction: SRC — HSP90AA1 (physical association, biophysical) Hutchison et al., J Biol Chem 1992*
• IRef Hprd Interaction: SRC — HSP90AA1 (in vivo) Hutchison et al., J Biol Chem 1992*
• IRef Ophid Interaction: SRC — HSP90AA1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: SRC — HSP90AA1 (aggregation, confirmational text mining) Hutchison et al., J Biol Chem 1992*

Text-mined interactions from Literome

Ren et al., Oncogene 2006 : c-Src also increases binding of MUC1 to HSP90 in cells
Duval et al., Mol Biol Cell 2007 : Src mediated phosphorylation of Hsp90 in response to vascular endothelial growth factor ( VEGF ) is required for VEGF receptor-2 signaling to endothelial NO synthase ... Tyrosine phosphorylation of Hsp90beta in response to VEGF is dependent on internalization of the VEGFR-2 and on Src kinase activation
Crèvecoeur et al., Biochem Pharmacol 2008 : We conclude that c-Src requires Hsp90 for its tyrosine kinase activity, and its inhibition by GA blocks c-Src dependent signalling pathways, such as NF-kappaB activation induced by sodium pervanadate
Yano et al., Proc Natl Acad Sci U S A 2008 (Bone Neoplasms...) : Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone
Colello et al., J Cell Sci 2010 : Androgen and Src signaling regulate centrosome activity
Liu et al., Oncol Rep 2011 (Prostatic Neoplasms) : Concomitantly with these findings, we demonstrated that the inhibition of cell surface Hsp90 not only inhibited the FN-dependent association between FAK, c-Src and integrin ß1, but also significantly inhibited the phosphorylation of FAK and c-Src, as well as their downstream targets paxillin and p130Cas
Desjardins et al., Arterioscler Thromb Vasc Biol 2012 : Interestingly, the association of AHA1 with Hsp90 is increased after c-Src mediated phosphorylation of Hsp90 on Tyr-300
Barabutis et al., Am J Physiol Lung Cell Mol Physiol 2013 : LPS induces pp60c-src mediated tyrosine phosphorylation of Hsp90 in lung vascular endothelial cells and mouse lung