Gene interactions and pathways from curated databases and text-mining

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FGF2 — IGFBP4

Text-mined interactions from Literome

De Los Rios et al., J Cell Physiol 2000 : Neither growth hormone (GH), fibroblast growth factor-2 , nor thyroxine ( T ( 4 ) ) had any effect on IGFBP expression or release
Pons et al., Endocrinology 1992 : While IGFBP levels in neuronal cultures were greatly increased by bFGF , their production by glial cells was inhibited
Contois et al., J Biol Chem 2012 : We report for the first time that IGFBP-4 differentially inhibits angiogenesis induced by distinct growth factor signaling pathways as IGFBP-4 inhibited FGF-2- and IGF-1 stimulated angiogenesis but failed to inhibit VEGF induced angiogenesis
Kummer et al., Endocrinology 1996 : The stimulatory effect of bFGF and IGF-I on IGFBP production was apparent after a 2- to 3-day exposure of the mesencephalic cultures to the peptides ... We propose that the up-regulation of IGFBP-4 by IGF-I and bFGF may serve to localize IGF-I to sites of action in the nervous system and thereby potentiate the neurotrophic actions of IGF-I