UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

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ITGA4 — ITGA5

Pathways - manually collected, often from reviews:

KEGG Focal adhesion: ACTN1/ACTN2/ACTN3/ACTN4 → Complex of 21 proteins (protein-protein, binding/association)
KEGG Focal adhesion: FLNA/FLNB/FLNC → Complex of 21 proteins (protein-protein, binding/association)
KEGG Focal adhesion: TLN1/TLN2 → Complex of 21 proteins (protein-protein, binding/association)
KEGG Focal adhesion: PXN → Complex of 21 proteins (protein-protein, binding/association)
KEGG Focal adhesion: VASP → Complex of 21 proteins (protein-protein, binding/association)
KEGG Focal adhesion: PARVA/PARVB/PARVG → Complex of 21 proteins (protein-protein, binding/association)
KEGG Focal adhesion: CHAD/COL11A1/COL11A2/COL1A1/COL1A2/COL2A1/COL3A1/COL4A1/COL4A2/COL4A4/COL4A5/COL4A6/COL5A1/COL5A2/COL5A3/COL6A1/COL6A2/COL6A3/COL6A6/COMP/FN1/IBSP/LAMA1/LAMA2/LAMA3/LAMA4/LAMA5/LAMB1/LAMB2/LAMB3/LAMB4/LAMC1/LAMC2/LAMC3/RELN/SPP1/THBS1/THBS2/THBS3/THBS4/TNC/TNN/TNR/TNXB/VTN/VWF → Complex of 21 proteins (protein-protein, activation)
KEGG Dilated cardiomyopathy: Complex of 21 proteins → ACTB/ACTG1 (protein-protein, binding/association)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Intact Interaction: Complex of 168 proteins (association, cross-linking study) Byron et al., Proteomics 2012
IRef Intact Interaction: Complex of 400 proteins (association, cross-linking study) Humphries et al., Science signaling 2009

Text-mined interactions from Literome

Shibayama et al., Blood 1999 : These data indicate that H-Ras and PLC, but not Raf-1, MAPK kinase, or the MAPK pathway, are involved in the inside-out signaling pathway of IL-3 induced VLA-4 and VLA-5 activation in Baf3 cells
Yuan et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2004 : The expression of CD49d , Cd44 and CD61L on Sca-1 ( + ) cells were similar to that befor expression ( P < 0.05 ), but the expression of CD49e and CD11a on Sca-1 ( + ) cells were remarkably increased ( P < 0.05 )