◀ Back to FOS
FOS — JUNB
Pathways - manually collected, often from reviews:
-
NCI Pathway Database AP-1 transcription factor network:
Elf1 (ELF1)
→
JUNB/FOS complex (JUNB-FOS)
(transcription, activates)
Wang et al., Mol Cell Biol 1994*
Evidence: reporter gene, physical interaction
-
NCI Pathway Database AP-1 transcription factor network:
JUNB/FOS complex (JUNB-FOS)
→
GM-CSF (CSF2)
(transcription, activates)
Wang et al., Mol Cell Biol 1994*
Evidence: reporter gene, physical interaction
-
NCI Pathway Database AP-1 transcription factor network:
JUNB/JUN-FOS complex (JUNB-FOS_JUN)
→
DMTF1 (DMTF1)
(transcription, activates)
Sreeramaneni et al., Mol Cell Biol 2005
Evidence: reporter gene, physical interaction, other species
-
NCI Pathway Database AP-1 transcription factor network:
JUNB/FOS complex (JUNB-FOS)
→
PEBPB2 (CBFB)
(transcription, activates)
Licht et al., J Cell Biol 2006*
Evidence: mutant phenotype, reporter gene, physical interaction, other species
-
NCI Pathway Database AP-1 transcription factor network:
JUNB (JUNB)
→
JUN-FOS (FOS/JUN)
(modification, collaborate)
Sreeramaneni et al., Mol Cell Biol 2005
Evidence: physical interaction
-
NCI Pathway Database AP-1 transcription factor network:
JUNB (JUNB)
→
JUNB/JUN-FOS complex (JUNB-FOS_JUN)
(modification, collaborate)
Sreeramaneni et al., Mol Cell Biol 2005
Evidence: physical interaction
-
NCI Pathway Database AP-1 transcription factor network:
JUN-FOS (FOS/JUN)
→
JUNB/JUN-FOS complex (JUNB-FOS_JUN)
(modification, collaborate)
Sreeramaneni et al., Mol Cell Biol 2005
Evidence: physical interaction
-
NCI Pathway Database AP-1 transcription factor network:
JUNB (JUNB)
→
FOS (FOS)
(modification, collaborate)
Ryseck et al., Oncogene 1991, Suzuki et al., Nucleic Acids Res 1991, Zerial et al., EMBO J 1989*, Chiu et al., Cell 1989*, Nakabeppu et al., Cell 1988*, Wang et al., Mol Cell Biol 1994*
Evidence: physical interaction
-
NCI Pathway Database AP-1 transcription factor network:
JUNB (JUNB)
→
JUNB/FOS complex (JUNB-FOS)
(modification, collaborate)
Ryseck et al., Oncogene 1991, Suzuki et al., Nucleic Acids Res 1991, Zerial et al., EMBO J 1989*, Chiu et al., Cell 1989*, Nakabeppu et al., Cell 1988*, Wang et al., Mol Cell Biol 1994*
Evidence: physical interaction
-
NCI Pathway Database AP-1 transcription factor network:
FOS (FOS)
→
JUNB/FOS complex (JUNB-FOS)
(modification, collaborate)
Ryseck et al., Oncogene 1991, Suzuki et al., Nucleic Acids Res 1991, Zerial et al., EMBO J 1989*, Chiu et al., Cell 1989*, Nakabeppu et al., Cell 1988*, Wang et al., Mol Cell Biol 1994*
Evidence: physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
FOS
—
JUNB
Newman et al., Science 2003
-
IRef Bind_translation Interaction:
FOS
—
JUNB
(array technology)
Newman et al., Science 2003
-
IRef Biogrid Interaction:
FOS
—
JUNB
(direct interaction, fluorescent resonance energy transfer)
Reinke et al., Science 2013
-
IRef Dip Interaction:
Complex of JUNB-MECOM-FOS
(anti bait coimmunoprecipitation)
Bard-Chapeau et al., Proc Natl Acad Sci U S A 2012
-
IRef Dip Interaction:
Complex of JUN-FOSB-MECOM-JUNB-YY1-FOS-FOSL2
(anti bait coimmunoprecipitation)
Bard-Chapeau et al., Proc Natl Acad Sci U S A 2012
-
IRef Hprd Interaction:
FOS
—
JUNB
(in vitro)
Chen et al., J Biol Chem 2000*, Hsu et al., Mol Cell Biol 1992*, Miyamoto-Sato et al., Genome Res 2005
-
IRef Hprd Interaction:
FOS
—
JUNB
(in vivo)
Chen et al., J Biol Chem 2000*, Hsu et al., Mol Cell Biol 1992*, Miyamoto-Sato et al., Genome Res 2005
-
IRef Intact Interaction:
FOS
—
JUNB
(physical association, protein complementation assay)|MI:0228)
Liu et al., EMBO J 2006*
-
IRef Intact Interaction:
FOS
—
JUNB
(physical association, display technology)
Miyamoto-Sato et al., PloS one 2010
-
IRef Ophid Interaction:
FOS
—
JUNB
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Robinson et al., Int J Cancer 2001
(Mouth Neoplasms...) :
Increased expression of
JunB in the transfected cells
resulted in up-regulation of c-Jun and Fra1 and an enhanced
AP-1 activity as demonstrated by transcriptional activation of the prototypic AP-1 dependent promoter, MMP-1
Medicherla et al., Mech Ageing Dev 2001
:
The observed decrease in
AP-1 binding activity in ageing adrenals is most likely
due to decreased expression of the AP-1 activating components ( c-Fos, c-Jun, JunD, etc. ) and increased expression of
JunB , resulting in a switch from transcriptionally active AP-1 complexes observed in young rats to less efficient JunB containing complexes in old rats
Finch et al., J Cancer Res Clin Oncol 2002
(Cell Transformation, Neoplastic...) :
JunB negatively
regulates AP-1 activity and cell proliferation of malignant mouse keratinocytes
Liu et al., Blood 2003
:
Exogenous
JunB restored
AP-1 DNA binding but did not prevent inhibition of macrosialin expression by C/EBPalpha-ER, indicating that JunB is not the only target relevant to inhibition of monopoiesis by C/EBPalpha
Hsu et al., Mol Cell Biol 1992
:
In liver cells, high levels of c-Fos/c-Jun,
c-Fos/JunB , LRF-1/c-Jun, and LRF-1/JunB complexes are present for several hours after the G0/G1 transition, and the relative level of
LRF-1/JunB complexes
increases during G1 ... LRF-1/c-Jun, c-Fos/c-Jun, and
c-Fos/JunB activate specific AP-1 and ATF site containing promoters, and in contrast, LRF-1/JunB potently
represses c-Fos- and c-Jun mediated activation of these promoters ... LRF-1/c-Jun, c-Fos/c-Jun, and c-Fos/JunB activate specific
AP-1 and ATF site containing promoters, and in contrast,
LRF-1/JunB potently
represses c-Fos- and c-Jun mediated activation of these promoters
Friedman et al., Blood Cells Mol Dis 2003
:
Exogenous
JunB restores
AP-1 DNA binding but does not overcome inhibition of monopoiesis by C/EBPalpha-ER
Sinitsyna et al., Toxicol Appl Pharmacol 2010
:
Without arsenite treatment, binding of
JunB and Fra1 was readily
detected in nuclear extracts from preconfluent cultures and was not detected a week after confluence, while
c-Fos was detected only after confluence
Brooks et al., Mol Immunol 1995
(Thymoma) :
Interleukin 1 activation of the
AP-1 transcription complex in murine T cells is
regulated at the level of
Jun B protein accumulation ... Thus, the stimulation of
AP-1 mediated gene expression by IL-1 in EL4 cells is
due to the promotion of
Jun B protein accumulation that, in turn, facilitates Jun B heterodimerization with TPA induced Fra-1 protein, thereby forming an active AP-1 complex
Tanguay et al., Cell Immunol 1994
:
Activation of
AP-1 in primary B lymphocytes by surface immunoglobulin
requires de novo
Jun-B synthesis
Hsu et al., Cancer Res 1993
:
Unlike c-Jun,
JunB represses several
AP-1 or activator of transcription factor site containing promoters, and this inhibition is greatly enhanced in the presence of LRF-1
Cook et al., Mol Cell Biol 1999
:
In cells expressing a conditionally active form of Raf-1 ( DeltaRaf-1 : ER ), we observed that selective, sustained activation of Raf-MEK-MAPK was sufficient to induce expression of Fra-1, Fra-2, and
JunB but, interestingly,
induced little or no
c-Fos or c-Jun