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MGMT — TP53

Text-mined interactions from Literome

Nutt et al., Carcinogenesis 1999 : Although these studies support a role for p53 regulation of MGMT in neonatal mouse astrocytes, BCNU resistance in wild-type cells appears to be mediated by a non-MGMT mechanism
Srivenugopal et al., Clin Cancer Res 2001 : We used isogenic human tumor cell lines to investigate the specific and direct effects of wild-type ( wt ) p53 on the expression of O(6)-methylguanine-DNA methyltransferase ( MGMT ), a DNA repair protein that confers tumor resistance to many anticancer alkylating agents ... The negative regulation of MGMT expression by wt p53 was confirmed in two other human isogenic cell lines, namely, the GM47.23 glioblastoma, which contains a dexamethasone-inducible wt p53, and the H460 lung cancer cell line, in which wt p53 had been inactivated by the human papillomavirus E6 protein
Blough et al., Cancer Res 2007 (Glioma) : O6-methylguanine-DNA methyltransferase regulation by p53 in astrocytic cells ... In this study, we tested the hypothesis that MGMT is regulated by p53 in astrocytic cells, the precursors of which may give rise to glioblastoma ... However, in knockout murine astrocytes and wild-type cells in which p53 was inhibited by RNAi, MGMT expression was reduced by > 90 % ... This effect of p53 on MGMT expression was unrelated to MGMT promoter methylation-in both wild-type and p53-null astrocytes, the MGMT promoter was unmethylated ... In murine astrocytes and SF767 cells, p53 regulates MGMT expression without affecting promoter methylation ; in astrocytes, this effect may be due to direct binding of p53 to the MGMT promoter
Natsume et al., Cancer Chemother Pharmacol 2008 (Eye Neoplasms...) : ( 2 ) MGMT promoter activity was suppressed by either adenovirally transduced p53 or IFN-beta
Zheng et al., Mol Cancer Ther 2008 (Melanoma...) : We show that accumulation of functional p53 is essential for IL-24 induced down-regulation of MGMT
Bocangel et al., Anticancer Res 2009 (Colonic Neoplasms...) : p53 Mediated down-regulation of the human DNA repair gene O6-methylguanine-DNA methyltransferase ( MGMT ) via interaction with Sp1 transcription factor ... MGMT expression is down-regulated by wild-type p53 ( WTp53 ) in human tumor cells ... Sp1 overexpression abrogated the inhibitory effect of p53 on the MGMT promoter activity in a dose dependent manner ... Taken together, these results suggest that sequestration of Sp1 could be one of the mechanisms by which p53 negatively regulates MGMT expression, thus enhancing sensitivity of tumor cells to O ( 6 ) -alkylguanine generating drugs
Bobustuc et al., Neuro Oncol 2010 (Glioblastoma) : Levetiracetam enhances p53 mediated MGMT inhibition and sensitizes glioblastoma cells to temozolomide
Liu et al., Zhonghua Jie He He Hu Xi Za Zhi 2010 (Carcinoma, Non-Small-Cell Lung...) : The loss of expression of MGMT may lead to activation of the wild-type p53
Grombacher et al., Oncogene 1998 (Liver Neoplasms, Experimental) : p53 is involved in regulation of the DNA repair gene O6-methylguanine-DNA methyltransferase ( MGMT ) by DNA damaging agents ... To study the effect of p53 on induction of the MGMT gene, we compared the presence of functional wild-type ( wt ) and mutant p53 with MGMT expression level in various mouse fibroblasts and rat hepatoma cell lines upon genotoxic treatment