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NOD1 — RELA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Bertin et al., J Biol Chem 1999
:
CARD4 interacted with the serine-threonine kinase RICK and potently
induced NF-kappaB activity through TRAF-6 and NIK signaling molecules
Inohara et al., J Biol Chem 1999
:
Unlike Apaf-1,
Nod1 induced activation of
nuclear factor-kappa-B (NF-kappaB) and bound RICK, a CARD containing kinase that also induces NF-kappaB activation ...
Nod1 mutants
inhibited NF-kappaB activity induced by RICK, but not that resulting from tumor necrosis factor-alpha stimulation
Inohara et al., J Biol Chem 2000
:
Nod1 is an Apaf-1-like molecule composed of a caspase-recruitment domain ( CARD ), nucleotide binding domain, and leucine-rich repeats that associates with the CARD containing kinase RICK and
activates nuclear factor kappaB (NF-kappaB)
Chin et al., Nature 2002
(Listeriosis...) :
Rip2-deficient macrophages infected with L. monocytogenes or treated with lipopolysaccharide (LPS) have decreased activation of NF-kappaB, whereas dominant negative Rip2 inhibited
NF-kappaB activation
mediated by Toll-like receptor 4 and
Nod1
Sen et al., J Immunol 2003
(Diabetes Mellitus, Type 1) :
Furthermore, increased
NF-kappaB activation
resulted in an enhanced capacity of
NOD vs NOR or BALB/c Mphi to secrete IL-12 ( p70 ), TNF-alpha, and IL-1alpha, which was inhibited upon infection with an adenoviral recombinant encoding a modified form of IkappaBalpha
Stehlik et al., J Biol Chem 2003
:
CARD6 is a modulator of
NF-kappa B activation by
Nod1- and Cardiak mediated pathways ... In transfection experiments, the CARD6 protein suppressed
NF-kappa B induction by
Nod1 or Cardiak but did not interfere with NF-kappa B activation by the CARD containing adapter protein Bcl10 or the cytokine tumor necrosis factor-alpha, demonstrating specificity of CARD6 for Nod-1 and Cardiak dependent pathways ... Thus, CARD6 represents a selective modulator of
NF-kappa B activation by Cardiak and
Nod1 , adding to the repertoire of CARD-family proteins implicated in inflammatory responses and innate immunity
Kim et al., Infect Immun 2004
(Enteritis...) :
Stable expression of dominant negative ( DN )
Nod1 in colon epithelial cells
prevented IkappaB kinase and NF-kappaB activation in response to infection with enteroinvasive Escherichia coli ... Stable expression of dominant negative ( DN )
Nod1 in colon epithelial cells
prevented IkappaB kinase and
NF-kappaB activation in response to infection with enteroinvasive Escherichia coli
Damiano et al., Biochem J 2004
:
NF-kappaB ( nuclear factor kappaB ) reporter assays demonstrated that co-expression of either full-length CLAN or the NACHT domain of CLAN significantly inhibited
NF-kappaB activation
induced by
Nod1 or Nod2 overexpression
Watanabe et al., Nat Immunol 2004
(Crohn Disease) :
Moreover,
NOD2 deficiency or the presence of a Crohn disease-like Card15 mutation
increased Toll-like receptor 2-mediated activation of
NF-kappa B-c-Rel , and T ( H ) 1 responses were enhanced
Opitz et al., Circ Res 2005
:
In conclusion, we demonstrated that C pneumoniae induced a
Nod1 mediated and Nod2 mediated
NF-kappaB activation in HEK293 cells
Li et al., J Cell Sci 2005
:
Overexpression of TRIP6 potentiates NF-kappaB activation by TNF, IL-1, TLR2 or Nod1, whereas a dominant negative mutant or RNA-interference construct of TRIP6 inhibits
NF-kappaB activation by TNF, IL-1, TLR2 or
Nod1
Opitz et al., J Immunol 2006
:
RNA interference and Nod1-overexpression experiments demonstrated that
Nod1 is critically
involved in chemokine secretion and
NF-kappaB activation initiated by L. monocytogenes in human endothelial cells ... In conclusion, L. monocytogenes induced a
Nod1 dependent
activation of p38 MAPK signaling and
NF-kappaB which resulted in IL-8 production in endothelial cells
Welter-Stahl et al., Cell Microbiol 2006
(Chlamydia Infections) :
We find that overexpression of a dominant negative
Nod1 or depletion of Nod1 by RNA interference
inhibits partially the activation of
NF-kappaB during chlamydial infection in vitro, suggesting that Nod1 can detect the presence of Chlamydia
Rosenstiel et al., Cell Microbiol 2006
(Chronic Disease...) :
Expression of
NOD1 and NOD2 significantly sensitized HEK293 cells to H. pylori
induced NF-kappaB activation in a cag pathogenicity island ( cagPAI ) -dependent manner
Yamamoto-Furusho et al., J Biol Chem 2006
:
Functionally, CENTB1 overexpression inhibited
NOD1- and NOD2 dependent
activation of
NF-kappaB , whereas small inhibitory RNA against CENTB1 increased NF-kappaB activation following NOD1- or NOD2 mediated recognition of the bacterial components gamma-d-glutamyl-meso-diaminopimelic acid and muramyl dipeptide, respectively
Wolfert et al., Infect Immun 2007
:
It was found that a diaminopimelic acid (DAP) containing muramyl tetrapeptide could activate
NF-kappaB in a
NOD1 dependent manner, demonstrating that an exposed DAP is not essential for NOD1 sensing
Barton et al., Eur Respir J 2007
:
Nod1 has been shown to
activate nuclear factor (NF)-kappaB ... Activation of
Nod1 in these cells
resulted in modest activation of
NF-kappaB , together with strong activation of the C/EBP transcription factors, particularly C/EBPbeta
Hasegawa et al., EMBO J 2008
:
A critical role of RICK/RIP2 polyubiquitination in
Nod induced
NF-kappaB activation ... However, the mechanism by which RICK activates
NF-kappaB in
response to
Nod1 and Nod2 stimulation is unknown ... Thus, RICK polyubiquitination links TAK1 to IKK complexes, a critical step in
Nod1/Nod2 mediated
NF-kappaB activation
Dufner et al., Mol Cell Biol 2008
:
RIP2 mediates
NF-kappaB activation
induced by the intracellular nucleotide binding oligomerization domain (
NOD ) receptors that sense bacterial peptidoglycan
Shaw et al., Curr Opin Immunol 2008
:
Stimulation of
NOD1 and NOD2, two prototypic NLRs,
results in the activation of MAPK and
NF-kappaB
Fukazawa et al., PLoS Pathog 2008
(Dysentery, Bacillary) :
GEF-H1 mediated control of
NOD1 dependent
NF-kappaB activation by Shigella effectors
Mulla et al., Am J Reprod Immunol 2009
:
In addition,
Nod1 and Nod2 mRNA expression was upregulated following treatment of trophoblast cells with lipopolysaccharide (LPS), and this was significantly
reduced by the presence of a
NFkappaB inhibitor and a TLR4-dominant negative ( DN )
Lee et al., J Biol Chem 2009
(Inflammatory Bowel Diseases) :
In support for this, we identified a role for SLC15A4, an oligopeptide transporter expressed in early endosomes, in
Nod1 dependent
NF-kappaB signaling
Lappas et al., Biol Reprod 2013
:
Agonist activation of
NOD1 and NOD2 by bacterial products leads to NFKB activation and transcription of
NFKB induced prolabor genes