Gene interactions and pathways from curated databases and text-mining

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ICAM1 — PHKA2

Text-mined interactions from Literome

Rodríguez-Fernández et al., Mol Biol Cell 1999 : Furthermore, the interaction of the activated integrin LFA-1 with its ligand intercellular adhesion molecule 1 induced the activation of the cytoplasmic tyrosine kinases focal adhesion kinase ( FAK ) and proline-rich tyrosine kinase 2 (PYK-2)
Rodríguez-Fernández et al., J Leukoc Biol 2002 (Calcium Signaling) : Most importantly, Ca(2) ( + ) mobilization did not induce activation of PYK2 when the LFA-1/ICAM-1 interaction was prevented with function blocking mAb, implying that the Ca(2) ( + ) -induced activation of PYK2 requires integrin engagement