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NOX5 — PLA2G4A
Text-mined interactions from Literome
Levy et al., Adv Exp Med Biol 2000
:
Cytosolic phospholipase A2 is
required for the activation of the
NADPH oxidase associated H+ channel in phagocyte-like cells ... In order to elucidate the mechanism by which cPLA2 regulates the oxidase, the
role of
cPLA2 in
NADPH oxidase associated H+ channel was studied
Pessach et al., J Biol Chem 2001
:
In this study we used this model to investigate the physiological
role of
cPLA(2) in regulation of
NADPH oxidase associated diaphorase activity
Zhao et al., J Biol Chem 2002
:
Cytosolic phospholipase A2 (cPLA2) regulation of human monocyte
NADPH oxidase activity ... In this study, we investigated the mechanisms involved in
cPLA(2) regulation of
NADPH oxidase activation by evaluating the effects of cPLA(2) on translocation and phosphorylation of p67(phox) and p47(phox) ... These results suggest that one mechanism of
cPLA(2) regulation of
NADPH oxidase activity is to control the arachidonate-sensitive assembly of the complete oxidase complex through modulating the translocation of both p47(phox) and p67(phox)
Shmelzer et al., J Cell Biol 2003
:
The mechanism by which
cPLA2 regulates
NADPH oxidase activity is not known, particularly since the NADPH oxidase complex is localized in the plasma membranes of stimulated cells
Rubin et al., J Biol Chem 2005
(Inflammation...) :
Cytosolic phospholipase A2-alpha is necessary for platelet activating factor biosynthesis, efficient neutrophil mediated bacterial killing, and the innate immune response to pulmonary infection
: cPLA2-alpha does not
regulate neutrophil
NADPH oxidase activity
Levy et al., Biochim Biophys Acta 2006
:
In addition, it was reported that
cPLA2alpha also
regulates the
NADPH oxidase activation
Askarova et al., Neuroscience 2011
:
Ab ( RAGE ) as well as
NADPH oxidase inhibitor and ROS scavenger
suppressed Aß42 induced ERK1/2 and
cPLA2 phosphorylation in CECs ... At the same time, only Ab ( RAGE ), but neither
NADPH oxidase inhibitor nor ROS scavenger,
inhibited the ERK1/2 pathway and
cPLA2 phosphorylation in primary astrocytes