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PRKAA2 — TP53
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Jones et al., Mol Cell 2005
:
AMPK activation
induces phosphorylation of
p53 on serine 15, and this phosphorylation is required to initiate AMPK dependent cell-cycle arrest ...
AMPK induced
p53 activation promotes cellular survival in response to glucose deprivation, and cells that have undergone a p53 dependent metabolic arrest can rapidly reenter the cell cycle upon glucose restoration
Okoshi et al., J Biol Chem 2008
:
Taken together, our present findings suggest that
AMPK dependent transcriptional induction and phosphorylation of
p53 at Ser-46 play a crucial role in the induction of apoptosis under carbon source depletion
Drakos et al., Leukemia 2009
(Lymphoma, Mantle-Cell) :
Pharmacologic inhibition of
AMPK using compound C in nutlin-3A treated MCL cells harboring wt-p53 did not
affect the level of ( ser15 )
p-p53 , suggesting that the ( ser15 ) p-p53 -- > AMPK is the direction involved in the p53/AMPK/mTOR cross talk
Eid et al., J Biol Chem 2010
(Diabetes Mellitus...) :
AMP activated protein kinase (AMPK) negatively
regulates Nox4 dependent activation of
p53 and epithelial cell apoptosis in diabetes ... Pharmacologic activation of
AMPK by 5-aminoimidazole-4-carboxamide-1-riboside in OVE26 mice
attenuated Nox4 and
p53 expression
Zhang et al., J Biol Chem 2010
(Glioblastoma) :
In further studies, we found that activation of
AMPK is
involved in TMZ induced
p53 activation and subsequent p21, Noxa, and Bax up-regulation
Xie et al., Int J Mol Med 2011
(Carcinoma, Hepatocellular...) :
Furthermore, activation of
p53 and AMPK was detected in etoposide treated cells and inhibition of
AMPK triggered apoptosis through suppression of autophagy
Chen et al., J Cell Physiol 2011
(Melanoma, Experimental) :
AMPK activation is
involved in vincristine induced
p53 phosphorylation and stabilization, the latter is known to mediate melanoma cell apoptosis
Ido et al., PloS one 2012
:
As reported by others, we found that
AMPK activation by itself
increased p53 phosphorylation at S15 in embryonic fibroblasts ( MEF ), whereas under the same conditions it decreased p53 phosphorylation in the keratinocytes, human aortic endothelial cells, and human HT1080 fibrosarcoma cells
Kim et al., Cell Signal 2013
(Breast Neoplasms) :
Inhibition of
AMPK blocked celastrol mediated
p53 phosphorylation ... Together, these results suggest that celastrol may have anti-tumor effects on MCF-7 cells via
AMPK induced
p53 and PLK-2 pathways