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CSF2 — RUNX1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Elsässer et al., Oncogene 2003
(Leukemia, Myeloid, Acute...) :
An autocrine mechanism involving granulocyte-colony stimulating factor ( G-CSF ) and G-CSF receptor (G-CSF-R) might participate in AML1-ETO mediated JNK signaling, because
AML1-ETO induces G-CSF and
G-CSF-R expression, and G-CSF-R neutralizing antibodies reduce AML1-ETO induced JNK phosphorylation
Rossetti et al., BMC genomics 2007
(Leukemia, Myeloid...) :
We interrogated mouse gene expression microarrays with probes generated either from 32D cells infected with a retroviral vector carrying
AML1-MTG16 and unable of granulocyte differentiation and proliferation in
response to the granulocyte
colony stimulating factor ( G-CSF ), or from 32D cells infected with the cognate empty vector
LaFiura et al., Oncogene 2008
(Leukemia, Myeloid, Acute...) :
When transfected into HeLa cells, only
AML1b , and not the in-frame A1E forms,
transactivated the
GM-CSF promoter ... In co-transfection experiments, the effects of A1E proteins on
GM-CSF transactivation by
AML1b ranged from repressive to activating
Liu et al., Leukemia 2009
(Acute Disease...) :
Additionally, AML1a represses transcription of promoter of macrophage
colony stimulating factor receptor
mediated by
AML1b , indicating that AML1a antagonized the effect of AML1b
Oakford et al., Leuk Res 2010
:
For example, the
GM-CSF gene is
activated by
RUNX1 , but is repressed by RUNX1-ETO
Frank et al., Oncogene 1995
:
Our data demonstrate that
AML1B , but not AML1A or AML1/ETO
transactivates the
GM-CSF promoter, requiring the TGTGGT sequence contained between base pairs -68 and -53 ... Although
AML1/ETO does not
stimulate the transcription of
GM-CSF , it may function by inhibiting the normal activity of AML1B in AML cells with the t ( 8 ; 21 ) translocation
Zhang et al., Mol Cell Biol 1996
:
CCAAT enhancer binding protein (C/EBP) and
AML1 ( CBF alpha2 ) synergistically
activate the macrophage
colony stimulating factor receptor promoter