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MAPK8 — S100B
Text-mined interactions from Literome
Riuzzi et al., J Cell Physiol 2006
:
S100B stimulates myoblast proliferation and inhibits myoblast differentiation by independently stimulating ERK1/2 and
inhibiting p38
MAPK ... The inhibitory
effect of
S100B on p38
MAPK translates into a defective induction of the muscle-specific transcription factor myogenin and the antiproliferative factor p21 ( WAF1 ), while S100B 's stimulatory effect on ERK1/2 results in stimulation of myoblast proliferation via cyclin D1 induction and Rb phosphorylation and protection against apoptosis via activation of NF-kappaB transcriptional activity
Schmidt et al., J Neural Transm 2007
:
By contrast, in FL-RAGE cells but not in Delta-RAGE cells
S100B and AGEs
activate p42/44
MAPK , augment cyclin D(1)/cdk4 protein and RNA levels and the transition into the S-phase
Ralay Ranaivo et al., Brain Res 2010
(MAP Kinase Signaling System) :
Albumin activated ERK1/2, p38
MAPK and JNK signaling pathways in astrocytes, and
induced the production of interleukin (IL)-1beta, inducible nitric oxide (NO) synthase, the NO metabolite nitrite, and the chemokine CX3CL1 while reducing the level of
S100B