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:
Inhibition of PI-3K, Akt, and p70 ( S6k ) by overexpression of a dominant negative mutant of PI-3K ( Deltap85 ) impaired nickel induced HIF-1 transactivation
Shin et al., PloS one 2013
(Neovascularization, Pathologic...) :
Mechanistically, MEL specifically inhibited the EGF induced HIF-1a expression by suppressing the phosphorylation of ERK, mTOR and p70S6K