Fujita et al., J Oral Pathol Med 2002
:
SPARC stimulates the synthesis of OPG/OCIF, MMP-2 and DNA in human periodontal ligament cells
McClung et al., Neurosci Lett 2007
(Brain Neoplasms...) :
SPARC upregulates MT1-MMP expression, MMP-2 activation, and the secretion and cleavage of galectin-3 in U87MG glioma cells ... We have shown by cDNA array analysis that SPARC upregulates membrane type 1-matrix metalloproteinase ( MT1-MMP ) and matrix metalloproteinase-2 (MMP-2) transcripts ... Our data confirm that SPARC upregulates MT1-MMP levels and MMP-2 activity
Shankavaram et al., J Cell Physiol 1997
:
Because SPARC and monocytes/macrophages are prevalent at sites of inflammation and remodeling in which there is connective tissue turnover, we examined the effect of SPARC on monocyte matrix metalloproteinase ( MMP ) production