Luo et al., Eur J Cancer 2010
(Adenocarcinoma...) :
We examined the effect of HMGB1 on Kupffer cells (KCs) Kono et al., J Surg Res 2012
(Disease Models, Animal...) :
The purpose of this study was to investigate whether inhibition of Kupffer cells (KCs) affects the expression of high mobility group box 1 (HMGB1) and mortality in septic peritonitis
Chen et al., PloS one 2012
(Burns) :
As a result, HMGB1 in vitro upregulated expressions of TNF-a and IL-1ß of KCs in a dose dependent manner, and HMGB1 promoted KCs from burn rats to produce significantly more TNF-a and IL-1ß proteins than those from sham animals ... These results indicate that HMGB1 induces proinflammatory cytokines production of KCs after sever burn injury, and this process might be largely dependent on TLRs dependent MAPKs/NF-?B signal pathway
Yang et al., Immunobiology 2013
(Disease Models, Animal...) :
The aim of present study was to determine the role of the intracellular high-mobility group box 1 (HMGB1) in modulating the early activation of KCs during ALF