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TIMP3 — VEGFA
Text-mined interactions from Literome
Qi et al., Nat Med 2003
(Neovascularization, Pathologic) :
In this study we demonstrate the ability of TIMP3 to inhibit vascular endothelial factor ( VEGF ) -mediated angiogenesis and identify the potential mechanism by which this occurs :
TIMP3 blocks the binding of
VEGF to VEGF receptor-2 and inhibits downstream signaling and angiogenesis
Neill et al., J Biol Chem 2012
(Neovascularization, Pathologic) :
Decorin antagonizes the angiogenic network : concurrent inhibition of Met, hypoxia inducible factor 1a,
vascular endothelial growth factor A, and
induction of thrombospondin-1 and
TIMP3