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Hashimoto et al., Biochem Biophys Res Commun 1999 : The results showed that TNF-alpha induced p38 MAP kinase activation and interleukin-6 (IL-6) production by TRX 14 were less than those by the parental L cells and the control transfected L cells ( Neo-1 ) ... These results showed that overexpression of TRX negatively regulates p38 MAP kinase activation and p38 MAP kinase mediated IL-6 production by TNF-alpha stimulated cells, indicating that TRX is critical for p38 MAP kinase activation which regulates cytokine expression
Hsieh et al., FASEB J 2006 (MAP Kinase Signaling System) : Thioredoxin-ASK1 complex levels regulate ROS mediated p38 MAPK pathway activity in livers of aged and long lived Snell dwarf mice