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MAPK1 — VEGFC

Text-mined interactions from Literome

Hsieh et al., J Biomed Sci 2004 (Ascites...) : Pharmacological and genetic inhibition assays revealed that the cytoplasmic signaling molecule, p38 MAPK , and the transcriptional factor, NF-kappa B, are critically involved in the transcriptional activation of the VEGF-C gene by Her-2/NEU
Luangdilok et al., Eur J Cancer 2011 (Carcinoma, Squamous Cell...) : Inhibition of p38 MAPK suppressed EGF induced VEGF-C upregulation in CAL 27 cells, but inhibited EGF induced VEGF-A upregulation in Detroit 562 ... Taken together, our evidence suggests that both endogenous and exogenous EGFR activation induces VEGF-A expression requiring both PI3K and MAPK signalling whereas VEGF-C expression is dependent on MAPK , but not the PI3K or mTOR pathways in SCCHN cell lines
Yin et al., J Biol Chem 2011 : We demonstrate that VEGF-C binds to heparan sulfate purified from primary lymphatic endothelia, and activation of lymphatic endothelial Erk1/2 in response to VEGF-C is reduced by interference with heparin or pretreatment of cells with heparinase, which destroys heparan sulfate ... Silencing lymphatic heparan sulfate chain biosynthesis inhibited VEGF-C mediated Erk1/2 activation and abrogated VEGFR-3 receptor dependent binding of VEGF-C to the lymphatic endothelial surface ... VEGF-C mediated Erk1/2 phosphorylation was inhibited in Ndst1 silenced lymphatic endothelia, and scratch-assay responses to VEGF-C and FGF-2 were reduced in Ndst1-deficient cells
Quentmeier et al., BMC cancer 2012 (Leukemia...) : Western blot analyses were performed to examine the effect of VEGF-C on p42/44 MAPK activation ... Mature VEGF-C induced p42/44 MAPK activation in the KDR- /FLT4 ( + ) cell line OCI-AML1 verifying the model character of this cell line for VEGF-C signal transduction studies
Coso et al., PloS one 2012 : Furthermore, activation of PI3K/Akt by VEGF-C/VEGFR-3 resulted in phosphorylation of P70S6K, eNOS, PLC?1, and Erk1/2