Gene interactions and pathways from curated databases and text-mining

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ATR — RELA

Pathways - manually collected, often from reviews:

  • BioCarta atm signaling pathway: ATR/ATRIP/ATM complex (ATR-TREX1-ATM) → NF-kappa-B/I-kappa-B-alpha complex (NFKBIA-RELA) (protein ubiquitination, activates)
  • BioCarta atm signaling pathway: ATR/ATRIP/ATM complex (ATR-TREX1-ATM) → I-kappa-B-alpha/RELA/p50/ubiquitin complex (NFKBIA-RELA) (protein ubiquitination, activates)

Text-mined interactions from Literome

Campbell et al., Cancer Res 2006 (Bone Neoplasms...) : The mechanism through which cisplatin achieves these effects is different to daunorubicin and UV light but shows great similarity to the RelA regulatory pathway induced by the ARF tumor suppressor : cisplatin regulation of RelA requires ATR/Chk1 activity, represses Bcl-x ( L ) but not XIAP expression, and results in phosphorylation of RelA at Thr ( 505 )
Ravi et al., Mol Cell Biochem 2008 (Melanoma) : In addition, our study shows that ATM, but not ATM-Rad3 related (ATR) or DNA dependent protein kinase (DNA-PK) is involved in UV-induced NF-kappaB activation
Wu et al., EMBO J 2008 : Consequently, ATR represses NF-kappaB activation induced by replication stress ... Reduction or increase of ATR expression by RNA interference or overexpression increased or reduced ATM-NEMO association and NF-kappaB activation induced by HU