Gene interactions and pathways from curated databases and text-mining

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CXCL12 — CXCR2

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Amara et al., J Biol Chem 1999 : Importantly, the amino-terminal domain of SDF-1alpha which is required for binding to, and activation of, CXCR4 remains exposed after binding to HS and is recognized by a neutralizing monoclonal antibody directed against the first residues of the chemokine
Heidemann et al., J Biol Chem 2003 : Angiogenic effects of interleukin 8 ( CXCL8 ) in human intestinal microvascular endothelial cells are mediated by CXCR2
Rios-Santos et al., Am J Respir Crit Care Med 2007 (Disease Models, Animal...) : The NO donor S-nitroso-N-acetyl-d, l-penicillamine inhibited CXCL8 induced human neutrophil chemotaxis and CXCR2 expression on human and murine neutrophils
Neel et al., J Cell Sci 2007 : Expression of RhoB T19N and transfection of RhoB siRNA impaired sorting of CXCR2 to the lysosome after 3 hours of CXCL8 stimulation and impaired CXCL8 induced CXCR2 degradation ... In cells expressing the RhoB Q63L mutant, CXCR2 recycling through the Rab11a recycling compartment was impaired after 30 minutes of CXCL8 stimulation as was CXCL8 induced CXCR2 degradation
Hu et al., Circulation 2007 (Anoxia...) : In isolated myocytes, CXCR4 activation by SDF-1alpha resulted in increased phosphorylation of both ERK 1/2 and AKT and decreased phosphorylation of JNK and p38
Sierro et al., Proc Natl Acad Sci U S A 2007 : CXCL12 did not induce signaling through CXCR7 ; however, CXCR7 formed functional heterodimers with CXCR4 and enhanced CXCL12 induced signaling
Gouwy et al., J Leukoc Biol 2009 : In turn, the induced CXCL8 synergized with CCL2 for mononuclear cell chemotaxis, and the chemotactic effect was mediated by CXCR1/CXCR2 , because CXCL8 receptor antagonists or antibodies were capable of blocking the synergy, while keeping the responsiveness to CCL2 intact
Nasser et al., J Immunol 2009 : CXCL8 ( also known as IL-8 ) activates CXCR1 and CXCR2 to mediate neutrophil recruitment and trigger cytotoxic effect at sites of infection
Duda et al., Clin Cancer Res 2011 (Neoplasms) : CXCL12 ( SDF1alpha ) -CXCR4/CXCR7 pathway inhibition : an emerging sensitizer for anticancer therapies ?
Singh et al., Microvasc Res 2011 : Additionally, we examined the mechanism of CXCL8 dependent CXCR1 and/or CXCR2 mediated phenotypic changes by evaluating ERK phosphorylation and cytoskeletal rearrangement and observed inhibition of ERK phosphorylation and cytoskeletal rearrangement in HMEC-1-shCXCR1, HMEC-1-shCXCR2 and HMEC-1-shCXCR1/2 cells
Mueller et al., PloS one 2013 (Immunologic Deficiency Syndromes...) : Upon stimulation by the endogenous ligand CXCL12 , CXCR4 becomes phosphorylated at multiple sites in its C-terminal domain