Matsui et al., Dev Growth Differ 2008
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Although FGF8b did not induce the upregulation of phospho-Smad2 , anti-FGF8b properties suppressed phospho-Smad2 in cultured blastoderm
Miyoshi et al., Mol Cell Endocrinol 2010
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Since the SAPK/JNK inhibitor inhibited FGF-8 effects in upregulating Id-1 transcription, SAPK/JNK appears to be involved in the mechanism by which FGF-8 enhances BMP-Smad signaling
Stuhlmiller et al., Development 2012
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Our results identify an early requirement for FGF/MAPK signaling in amniote neural crest induction and suggest an intriguing role for FGF mediated Smad inhibition in ectodermal development