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IL6 — NOX1
Text-mined interactions from Literome
Luchtefeld et al., Biochem Biophys Res Commun 2003
:
Angiotensin II (ANG II) induced
interleukin (IL)-6 synthesis
requires NAD ( P ) H-oxidase derived superoxide anions
Yamagishi et al., J Mol Cell Cardiol 2004
:
Pigment epithelium derived factor
inhibits TNF-alpha induced
interleukin-6 expression in endothelial cells by suppressing
NADPH oxidase mediated reactive oxygen species generation ... The results demonstrated that PEDF
inhibited TNF-alpha induced NF-kappaB activation and subsequent
IL-6 overexpression in HUVEC by suppressing
NADPH oxidase mediated ROS generation
Tojo et al., J Hypertens 2005
(Hypertension, Renal) :
Nicotinamide adenine dinucleotide phosphate (
NAD ( P ) H ) oxidase is
regulated by angiotensin II,
interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha via p38 mitogen activated protein kinase ( MAPK )
Yu et al., Int J Biochem Cell Biol 2005
:
NADPH oxidase mediates
interleukin-6 expression in cerulein stimulated pancreatic acinar cells ... We investigated whether pancreatic acinar cells contain NADPH oxidase, and whether
NADPH oxidase mediates
interleukin-6 (IL-6) in pancreatic acinar AR42J cells stimulated with cerulein ... NADPH oxidase inhibitor diphenylene iodonium ( DPI ), antioxidant rebamipide, and antisense oligonucleotides ( AS ODNs ) for NADPH oxidase subunits p22phox and p47phox were used to determine the
involvement of
NADPH oxidase in NF-kappaB activation and
IL-6 expression in AR42J cells
Cheng et al., Am J Physiol Gastrointest Liver Physiol 2006
(Disease Models, Animal...) :
In the circular muscle, PAF causes production of additional
IL-6 that
activates NADPH oxidase to induce production of H ( 2 ) O ( 2 )
Du et al., Biochem Biophys Res Commun 2007
:
Although PAO was also reported to inhibit NADPH oxidase, the inhibition of NADPH oxidase by its specific inhibitor, diphenylene iodonium ( DPI ) could not suppress beta-AR mediated IL-6 production, suggesting that
NADPH oxidase may not
contribute to the inhibitory effect of PAO on
IL-6 production
Turchan-Cholewo et al., Antioxid Redox Signal 2009
:
Furthermore, inhibition of
NADPH oxidase attenuated Tat induced release of
interleukin-6 (IL-6) , tumor necrosis factor alpha (TNF), and monocyte chemoattractant protein 1 ( MCP-1 ), and decreased microglial mediated neurotoxicity
Behrens et al., J Neurosci 2008
(Disease Models, Animal) :
Interleukin-6 mediates the increase in
NADPH-oxidase in the ketamine model of schizophrenia ... Here we show that neuronal production of
interleukin-6 (IL-6) is
necessary and sufficient for ketamine mediated activation of
NADPH-oxidase in brain ... Our results showing that ketamine induced
IL-6 is
responsible for the activation of
NADPH-oxidase in brain suggest that reducing brain levels of this cytokine may protect the GABAergic phenotype of fast spiking PV-interneurons and thus attenuate the propsychotic effects of ketamine
Zhang et al., Nephrology (Carlton) 2009
:
Role of
NAD ( P ) H oxidase in transforming growth factor-beta1 induced monocyte chemoattractant protein-1 and
interleukin-6 expression in rat renal tubular epithelial cells ... This study investigated the
role of
NAD ( P ) H oxidase in transforming growth factor-beta1 ( TGF-beta1 ) -induced reactive oxygen species ( ROS ) generation, monocyte chemoattractant protein-1 ( MCP-1 ), and
interleukin-6 (IL-6) expression in rat renal tubular epithelial NRK-52E cells
Lee et al., Cytokine 2010
:
Additionally, pharmacological inhibitor of
NADPH oxidase ( NOX ) significantly
attenuated IL-4 induced ROS generation and
IL-6 expression in HAEC
Tanabe et al., Journal of neuroinflammation 2010
(Glioma) :
Apocynin, an inhibitor of
NADPH oxidase that suppresses intracellular reactive oxygen species, significantly
suppressed TNF-alpha induced
IL-6 release and mRNA expression ... These results strongly suggest that TNF-alpha induces IL-6 synthesis through the JAK/STAT3 pathway in addition to p38 MAP kinase and SAPK/JNK in C6 glioma cells, and that phosphorylation of NFkappaB at Ser 536 and Ser 468, and
NADPH oxidase are
involved in TNF-alpha stimulated
IL-6 synthesis
Moe et al., J Cell Mol Med 2011
(Ventricular Remodeling) :
Nox2 and Nox4 siRNA significantly
attenuated TNF-a induced ROS and upregulation of IL-1ß and
IL-6 in cardiomyocytes
Hopps et al., J Sports Med Phys Fitness 2011
(Obesity) :
TNF-a and
IL-6 , produced by adipose tissue,
increase NADPH oxidase activity activating protein kinase C and NF?B leading to an higher oxidative stress
Donini et al., Prostate 2012
(Prostatic Neoplasms) :
LNCaP
enhance IL-1ß, IL-23,
IL-6 , and TNF-a secretion by decreasing glucan dependent NADPH oxidase activity, whereas glucan increases IL-12 production through
NADPH oxidase unrelated mechanisms