Parameswaran et al., J Biol Chem 2006
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We demonstrate that knockdown of arrestin-2 leads to enhanced LPS induced phosphorylation and degradation of p105 , enhanced TPL2 release, and enhanced MEK1/2 phosphorylation
Dhungana et al., Mol Cell Proteomics 2009
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Immunoblotting of DRMs revealed proteasome dependent activation of MEK and ERK specifically occurring in lipid rafts as well as proteasomal activity upon raft localized p105 that was enhanced by LPS Wang et al., Fish Shellfish Immunol 2013
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We further observed that LPS stimulation led to the degradation of Aj-p105 and the nuclear translocation of Aj-rel and Aj-p50