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EIF4EBP1 — MAPK3

Pathways - manually collected, often from reviews:

• WikiPathways 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression: EIF4EBP1 → Complex of MAPK1-MAPK3 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Ophid Interaction: MAPK3 — EIF4EBP1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Bhandari et al., Kidney Int 2001 : The requirement for Erk-1/-2 MAP kinase activation for 4E-BP1 phosphorylation by insulin suggests a cross-talk between PI 3-kinase and Erk-1/-2-type MAP kinase pathways
Wang et al., J Neurochem 2006 : Additionally, HA-induced phosphorylation of 4E-BP1 was dependent on MAPK signaling, indicating that RAW 264.7 cells exhibited higher levels of hyperphosphorylated 4E-BP1 possibly due to the overactivation of MAPK
Jiang et al., Planta Med 2007 (Stomach Neoplasms) : We found that matrine inactivated Erk1/2 , an upstream regulator of 4E-BP1 and eIF4E, and remarkably reduced the phosphorylation level of 4E-BP1 and eIF4E, whereas 4E-BP1 was little influenced by JNK, p38 or Akt/mTOR
Kleijn et al., FEBS Lett 1996 : This excludes a role for MAPK in NGF- and EGF induced PHAS-I phosphorylation in PC12 cells