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MAPK3 — TXN
Text-mined interactions from Literome
Kunchithapautham et al., Infect Immun 2003
:
Overexpression of
Bm-TRX-1 in a human monocyte cell line negatively regulated tumor necrosis factor alpha
induced p38
mitogen activated protein kinase activity, suggesting a possible role of the 16-kDa Bm-TRX-1 in immunomodulation
Kuster et al., Circulation 2005
(Hypertrophy) :
TRX1 overexpression
inhibited the alphaAR stimulated phosphorylation of MEK1/2,
ERK1/2 , and p90RSK and prevented cellular hypertrophy, sarcomere reorganization, and protein synthesis ( versus beta-galactosidase )
Hsieh et al., FASEB J 2006
(MAP Kinase Signaling System) :
Thioredoxin-ASK1 complex levels
regulate ROS mediated p38
MAPK pathway activity in livers of aged and long lived Snell dwarf mice
Limón-Pacheco et al., Free Radic Biol Med 2007
(MAP Kinase Signaling System) :
A time related GSH depletion in the liver and kidney correlated with p38 (
MAPK ) phosphorylation and
induction of
thioredoxin 1 (Tx-1) transcription
Li et al., Biochem Biophys Res Commun 2009
:
Up-regulation of thioredoxin interacting protein (Txnip) by p38
MAPK and FOXO1
contributes to the impaired
thioredoxin activity and increased ROS in glucose treated endothelial cells
Yang et al., Microbes Infect 2010
:
Japanese encephalitis virus down-regulates
thioredoxin and
induces ROS mediated ASK1-ERK/p38
MAPK activation in human promonocyte cells
Ren et al., FEBS Lett 2010
(MAP Kinase Signaling System) :
Knockdown of TXNIP in MMCs reversed HG-induced reduction of
TRX activity and
inhibited HG-induced activation of p38
MAPK and increased synthesis of TGF-beta1 and fibronectin