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NFKB1 — NGF
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Hamanoue et al., Mol Cell Neurosci 1999
:
Antibodies that block binding of NGF to the p75 receptor prevented
NGF induced
NF-kappaB activation and reduced the NGF survival response to the same extent as superrepressor IkappaB-alpha
Wooten et al., Cell Death Differ 1999
:
Furthermore, transfection of full-length antisense PKC-iota blocked basal and
NGF stimulated
NF-kappaB
Gentry et al., J Biol Chem 2000
(Neurilemmoma) :
Gel shift assays demonstrated activation of
NF-kappaB in
response to
NGF within 30 min and lasting at least 4 h. NGF also stimulated JNK in the cells ( detected by in vitro kinase assays ) with a similar time course ... These results suggest that
NGF activation of
NF-kappaB through the p75 receptor promotes survival, counterbalancing the pro-apoptotic signal
Wooten et al., Mol Cell Biol 2000
:
Src, PI3K, and PKC-iota were likewise required for
NGF induced
NF-kappaB activation and cell survival, whereas Ras was not required for either survival or NF-kappaB activation but was required for differentiation ... Consistent with a role for Src in regulating NF-kappaB activation, an absence of Src activity impaired recruitment of PKC-iota into an IKK complex and markedly impaired
NGF induced translocation of
p65/NF-kappaB to the nucleus
Bui et al., J Cell Biol 2001
:
NGF induced
NFkappaB activity and Bcl-xL expression were inhibited in cells overexpressing the NFkappaB inhibitor, IkappaBalpha ... Unlike tumor necrosis factor-alpha (TNF-alpha), however,
NGF induced
NFkappaB activation occurred without significant degradation of IkappaBs determined by Western blot analysis and time-lapse imaging of neurons expressing green fluorescent protein tagged IkappaBalpha ... Conversely, overexpression of a dominant negative mutant of TNF receptor associated factor-6 blocked TNF-alpha-, but not
NGF induced
NFkappaB activation ... We conclude that
NGF and TNF-alpha
induce different signaling pathways in neurons to activate
NFkappaB and bcl-x gene expression
Descamps et al., J Biol Chem 2001
(Breast Neoplasms) :
In contrast, the anti-apoptotic effect of
NGF ( studied using the ceramide analogue C2 )
required p75 ( NTR ) as well as the activation of the transcription factor
NF-kB , but neither p140(trkA) nor MAPK was necessary
Khursigara et al., J Neurosci 2001
:
Conversely, the expression of a dominant negative version of RIP2 protein resulted in a loss of
NGF induced
NF-kappaB induction and increased NGF mediated cell death
Cosgaya et al., J Neurochem 2001
:
Binding of
nerve growth factor to its p75 receptor in stressed cells
induces selective IkappaB-beta degradation and
NF-kappaB nuclear translocation ... In the present study we found that
NGF binding to p75 induces nuclear translocation of p65 and
increases NF-kappaB binding activity in a cell line overexpressing p75, but only after the cells have been subjected to a previous stress
Fiorentini et al., Mol Endocrinol 2002
(Pituitary Neoplasms...) :
Moreover,
NGF treatment of nonresponder cells
induced both nuclear translocation and DNA binding activity of
NF-kappaB complexes containing p50, p65/RelA, and cRel subunits, an effect prevented by anti-p75 ( NGFR ) antibodies ... These data indicate that in prolactinoma cells the effect of NGF on D ( 2 ) receptor expression is mediated by p75 ( NGFR ) in a trkA independent way and that
NGF stimulation of p75 ( NGFR )
activates NF-kappaB , which is required for D ( 2 ) gene expression
Zaheer et al., Neurochem Res 2001
:
The inductions of BDNF and
NGF were also
blocked by inhibitors of p38 and MEK, as well as by the inhibition of
NF-kappaB with a decoy DNA sequence
Halvorsen et al., Brain Res 2002
(MAP Kinase Signaling System...) :
Survival promoting MEK-ERK and PI3K pathways contribute to viability during MPP ( + ) exposure, both are
activated by
NGF , and loss of PI3K mediated signaling and
NF-kappa B-mediated transcription may commit cells irreversibly to apoptosis in this model
Oakley et al., Am J Pathol 2003
(Liver Cirrhosis) :
NGF regulates
nuclear factor (NF)-kappaB activity, reducing p50/p65 binding detected by electromobility shift assay and reduced NF-kappaB CAT reporter activities from both basal unstimulated levels and after NF-kappaB induction by tumor necrosis factor
Choi et al., Mol Pharmacol 2003
:
In PC-12 cells,
nerve growth factor (NGF), which
activates nuclear factor-kappaB (NF-kappaB) , maintained RACK1 levels and promoted cell survival in serum-free medium
Mamidipudi et al., J Biol Chem 2004
:
We have previously shown that the activity of the interleukin-1 (IL-1) receptor associated kinase ( IRAK ) is required for
nerve growth factor (NGF) induced
activation of
NF-kappaB and cell survival ( ( 2002 ) J. Biol. Chem. 277, 28010-28018 )
Wu et al., Cell Signal 2005
:
NGF stimulated phosphorylation of Bad and IKK and transcriptional activity of
NFkappaB were indeed sensitive to treatments with PTX
Wooten et al., J Biol Chem 2005
:
The p62 scaffold regulates
nerve growth factor induced
NF-kappaB activation by influencing TRAF6 polyubiquitination
Furuno et al., Neurosci Lett 2006
:
These results suggested that there is a close correlation between the signaling pathways via TNF receptors and neurotrophin receptors for the NF-kappaB activation, and that
NGF and BDNF
enhance TNF-alpha induced nuclear translocation of
NF-kappaB
Chen et al., J Biol Chem 2006
:
Overexpression of the NF-kappaB signaling super inhibitor mutant IkappaBalpha ( S32A/S36A ) abolished the effect of p65 and blocked
NGF induced activation of
NF-kappaB signaling, resulting in a significant reduction in dor promoter activity
Vilar et al., EMBO J 2006
:
In PC12 cells, Bex1 overexpression inhibited the
induction of
NF-kappaB activity by
NGF without affecting activation of Erk1/2 and AKT, while Bex1 knockdown accelerated neuronal differentiation and potentiated NF-kappaB activity in response to NGF
Heese et al., Cell Mol Immunol 2006
:
NF-kappaB regulates B-cell derived
nerve growth factor expression
Condello et al., Brain Res 2008
(Neuroblastoma) :
We hypothesize that NF-kappaB activation was dependent on the transamidating activity related to high levels of TG2, and
NGF enhanced
NF-kappaB activation by a different, synergistically acting, pathway
Arevalo et al., J Neurochem 2009
:
At 800 nM, Abeta ( 1-40 ) prevents
NGF induced activation of
NF-kappaB and consequently, it depresses the expression of Enhancer-of-split 1
Mogi et al., J Immunoassay Immunochem 2010
:
Down-regulation of
NF-kappaB led to up-regulation of
NGF production in mouse osteoblasts ... These findings demonstrate that the suitable suppression of
NF-kappaB nuclear translocation
induced NGF production in non-neuronal osteoblastic cells
Moubarak et al., J Neurosci 2010
:
Moreover,
NGF dependent activation of two main intracellular pathways involved in the regulation of neurite outgrowth, extracellular signal regulated kinases ( ERKs ) and
nuclear factor kappaB (NF-kappaB) , is impaired when endogenous FLIP-L is downregulated, although TrkA remains activated
Wood et al., Neurosci Lett 1995
:
Regulation of
NF-kappa B activity in rat dorsal root ganglia and PC12 cells by tumour necrosis factor and
nerve growth factor
Carter et al., Science 1996
:
Selective
activation of
NF-kappa B by
nerve growth factor through the neurotrophin receptor p75 ... In the absence of TrkA,
NGF binding to p75NGR
activated the transcription factor
nuclear factor kappa B (NF-kappa B) in rat Schwann cells
Tong et al., J Neurosci Res 1996
:
Effect of
nerve growth factor on AP-1,
NF-kappa B , and Oct DNA binding activity in apoptotic PC12 cells : extrinsic and intrinsic elements
Recio et al., J Biol Chem 1997
:
NGF does not
activate NF-kappaB in PC12 cells, but rather increases binding of other nuclear factors to the kappaB sequences
Heese et al., J Neurochem 1998
(Inflammation) :
To assess the
role of the transcription factor
nuclear factor-kappaB (NF-kappaB) in inflammatory mediator induced microglial
NGF expression, the effect of the NF-kappaB inhibitor pyrrolidine dithiocarbamate ( PDTC ) was analyzed ... In addition, microglial neurotoxicity mediating beta-amyloid peptides A beta ( 1-40 ) and A beta ( 1-42 ) failed to alter NGF synthesis, whereas A beta ( 25-35 ) specifically induced
NF-kappaB dependent microglial
NGF expression
Galve-Roperh et al., J Neurochem 1998
:
To clarify further the
role of
NF-kappaB in
NGF synthesis, electrophoretic mobility shift assays were performed with an NF-kappaB site from the NGF promoter ... The absence of significant binding of NF-kappaB to the NGF gene promoter indicates the existence of an indirect
role of
NF-kappaB in the regulation of
NGF synthesis