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IKBKB — SGK1
Text-mined interactions from Literome
Zhang et al., Cancer Res 2005
(Breast Neoplasms) :
We also show that SGK enhances the ability of IKKbeta to phosphorylate endogenous IkappaBalpha in cells or recombinant glutathione S-transferase-IkappaBalpha in vitro and increases IkappaBalpha degradation ;
SGK physically associates with and
activates IKKbeta in MDA231 cells via phosphorylation of Ser ( 181 ) in IKKbeta
Tai et al., J Biol Chem 2009
:
Although SGK1 does not phosphorylate IKKbeta,
IKKbeta activity is still
required for IKK complex activation and for
SGK1 phosphorylation and activation of NF-kappaB