Gene interactions and pathways from curated databases and text-mining

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LTF — TNF

Text-mined interactions from Literome

Zimecki et al., Arch Immunol Ther Exp (Warsz) 1999 : Lactoferrin increases the output of neutrophil precursors and attenuates the spontaneous production of TNF-alpha and IL-6 by peripheral blood cells
Choe et al., J Cell Biochem 1999 : Effect of lactoferrin on the production of tumor necrosis factor-alpha and nitric oxide ... We have tested the effect of lactoferrin on the productions of tumor necrosis factor-alpha and nitric oxide in some cells ... Lactoferrin itself did not induce either tumor necrosis factor-alpha production or nitric oxide production, but lipopolysaccharide stimulated tumor necrosis factor-alpha production of macrophages and monocytes were inhibited by lactoferrin treatment combined with stimulant
Zimecki et al., Inflamm Res 2003 (Jaundice, Obstructive) : The aim of this study was to evaluate effects of bovine lactoferrin ( BLF ) on histopathological changes in the liver of 14 day obstructive jaundiced ( OJ ) rats and production of tumor necrosis factor ( TNF-alpha ) and interleukin 6 (IL-6) by splenocytes from 7- and 14-day OJ rats
Gutteberg et al., APMIS 1991 (Sepsis) : Effect of Escherichia coli, Streptococcus agalactiae and tumor necrosis factor on lactoferrin release and the generation of tissue thromboplastin ... Using a whole blood in vitro model, we have investigated the effect of Escherichia coli ( E. coli ), Streptococcus agalactiae ( group B streptococci, GBS ) and tumor necrosis factor alpha (TNF) on the generation of lactoferrin (LF) , interleukin-1 beta (IL-1) and tissue thromboplastin (TPL) in healthy newborns at term and their mothers
Gutteberg et al., APMIS 1990 : The effect of Escherichia coli, Streptococcus agalactiae and tumor necrosis factor on the generation of lactoferrin ... Using an in vitro model, we report the early effect of Escherichia coli ( E. coli ), Streptococcus agalactiea ( group B streptococci, GBS ) and recombinant tumor necrosis factor alpha (TNF) on the release of lactoferrin (LF) and the generation of interleukin-1 (IL-1) due to E. coli, using heparinized whole blood from healthy full-term newborns
Willems et al., Immunology 1989 : TNF alpha induced lactoferrin release was enhanced by cytochalasin B pretreatment of the granulocytes, while GCP/IL-8 promoted degranulation was not
Balazovich et al., Blood 1996 : To determine if TNF alpha plays a role in H2O2 and lactoferrin release, we investigated the effect of anti-TNF alpha antibodies on FMLP stimulated activation of adherent PMN
Sorimachi et al., Biochem Mol Biol Int 1997 : Activation of macrophages by lactoferrin : secretion of TNF-alpha , IL-8 and NO ... Secretion of TNF-alpha peaked at 6 h of incubation in the presence of lactoferrin and then declined ... The effects of lactoferrin on the secretion of TNF-alpha , IL-8 and NO were dose dependent and lactoferrin had a significant effect on secretion of at concentrations greater than 10 mg/ml
Adamik et al., Arch Immunol Ther Exp (Warsz) 1998 (Critical Illness...) : We studied the effect of lactoferrin (LF) on the proliferative response of peripheral blood mononuclear cells ( PBMC ) to lipopolisaccharide (LPS) in vitro and its influence on production of 2 proinflammatory cytokines : interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) ... Lactoferrin alone was a good inducer of IL-6 and TNF-alpha production by monoclear cells in vitro ... Lactoferrin is a good inducer of IL-6 and TNF-alpha production
Mócsai et al., J Immunol 1999 : Human PMN incubated on fibrinogen released lactoferrin in response to TNF-alpha and this response was inhibited by PP1, a Src family tyrosine kinase inhibitor ... Double knockout hck-/- fgr-/- PMN adherent to collagen or fibrinogen failed to release lactoferrin in response to TNF-alpha but responded to PMA as wild-type PMN