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DCN — EGFR

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: DCN — EGFR (direct interaction, two hybrid) Santra et al., J Biol Chem 2002*
• IRef Biogrid Interaction: DCN — EGFR (direct interaction, pull down) Santra et al., J Biol Chem 2002*
• IRef Biogrid Interaction: DCN — EGFR (direct interaction, pull down) Iozzo et al., J Biol Chem 1999*
• IRef Hprd Interaction: DCN — EGFR (in vitro) Santra et al., J Biol Chem 2002*, Iozzo et al., J Biol Chem 1999*
• IRef Hprd Interaction: DCN — EGFR (two hybrid) Santra et al., J Biol Chem 2002*, Iozzo et al., J Biol Chem 1999*
• IRef Hprd Interaction: DCN — EGFR (in vivo) Santra et al., J Biol Chem 2002*, Iozzo et al., J Biol Chem 1999*
• IRef Ophid Interaction: DCN — EGFR (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Iozzo et al., Proc Natl Acad Sci U S A 1999 (Lymphoma, T-Cell...) : This process is caused by a decorin mediated activation of the epidermal growth factor receptor , which leads to a sustained induction of endogenous p21 ( WAF1/CIP1 ) ( the cyclin dependent kinase inhibitor p21 ) and growth arrest
Csordás et al., J Biol Chem 2000 (Calcium Signaling...) : We demonstrate that decorin causes a sustained down-regulation of the EGFR
Zhu et al., J Biol Chem 2005 : Decorin inhibits the epidermal growth factor receptor (EGFR) by down regulating its tyrosine kinase activity, thereby blocking the growth of a variety of transformed cells and tumor xenografts
Ma et al., Biol Pharm Bull 2008 : Meanwhile, decorin (DCN) , a specific antagonist of EGFR, can target the tumor cells enriched in EGFR and cause a significant downregulation of EGFR
Hu et al., Neoplasia (New York, N.Y.) 2009 (Prostatic Neoplasms) : Moreover, in human prostate cancer cells, we show that decorin specifically inhibits EGFR and AR phosphorylation and cross talk between these pathways
Patel et al., J Biol Chem 1998 : Decorin activates the epidermal growth factor receptor and elevates cytosolic Ca2+ in A431 carcinoma cells
Iozzo et al., J Biol Chem 1999 : Exogenous decorin activates the epidermal growth factor (EGF) receptor , thereby triggering a signaling cascade that leads to phosphorylation of mitogen activated protein ( MAP ) kinase, induction of p21, and growth suppression