Gene interactions and pathways from curated databases and text-mining

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EGFR — NOS2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Ma et al., Int J Cancer 2008 (Carcinoma...) : These data suggest that nuclear accumulation of EGFR and STAT3 activation by IL-6 play the key role in iNOS expression and resultant DNA damage, leading to EBV mediated NPC
Broadbelt et al., American journal of physiology. Renal physiology 2009 (Ureteral Obstruction) : This study examined the involvement of epidermal growth factor (EGF) receptor ( EGFR ), nuclear factor-kappaB (NFkappaB), and signal transducers and activators of transcription 3 ( STAT3 ) in iNOS induction in human proximal tubule ( HKC-8 ) cells in response to pressure or EGF ... These data indicate that EGFR , NFkappaB, and STAT3 are required for human iNOS gene induction in response to pressure or EGF, indicating a similar mechanism of activation
Li et al., Ann Surg Oncol 2012 (Adenocarcinoma...) : EGFR nuclear import in gallbladder carcinoma : nuclear phosphorylated EGFR upregulates iNOS expression and confers independent prognostic impact