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ECM2 — TNF

Text-mined interactions from Literome

Greenwel et al., Mol Cell Biol 2000 : The proinflammatory cytokine tumor necrosis factor alpha (TNF-alpha) inhibits ECM accumulation by stimulating the expression of matrix proteolytic enzymes and by downregulating the deposition of structural macromolecules such as type I collagen
Fernandes et al., Biorheology 2002 (Disease Models, Animal...) : By analogy, an inhibitor to the p55 TNF-alpha receptor may also provide a mechanism for abolishing TNF-alpha induced degradation of cartilage ECM by MMPs
Sérandour et al., Hepatology 2005 : TNFalpha promoted an extracellular matrix ( ECM ) degradation that involved the matrix metalloproteinase MMP-9 induction through activation of NF-kappaB pathway
Zhang et al., Biochim Biophys Acta 2008 : The extracellular matrix ( ECM ) of the vasculature is a major target of inflammatory cytokines, and TNFalpha regulates ECM metabolism by affecting collagen production
Bartlett et al., Immunol Cell Biol 1995 (Inflammation) : Thus, IL-1 + TNF enhanced neutrophil and EC degradation of the ECM but inhibited lymphocyte ECM degradation
Hershkoviz et al., Scand J Immunol 1993 : Moreover, the level of TNF secretion is greatly enhanced in the presence of physically damaged ECM ( dECM )
Ikewaki et al., Tissue Antigens 1996 (Lymphoma, Large B-Cell, Diffuse) : The U937 cells markedly adhered to the tumor necrosis factor-alpha (TNF-alpha) stimulated human umbilical vein endothelial cells ( HUVECs ) and also to the extracellular matrix protein , fibronectin, but mNI-58A did not enhance or block these adhesion process
Lee et al., Am J Physiol 1998 : With PSOC 867 exposure, where ECM protein synthesis is elevated, TNF-alpha and TGF-beta1 further increased both the absolute and relative rates of ECM synthesis on day 3 but had little effect on day 1