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ACTN1 — PXN

Pathways - manually collected, often from reviews:

• BioCarta erk and pi-3 kinase are necessary for collagen binding in corneal epithelia: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin (active1)/p130cas/FAK/CSK/Paxillin/Vinculin/alp complex (ITGA1-PTK2-BCAR1-ACTN3_ACTN2_ACTN1_ACTN4-ZYX-TLN1-ITGB1-VCL-PXN-CSK-ACTA1-TNS1-CAPN1) → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) (actin filament polymerization, collaborate)
  
• BioCarta erk and pi-3 kinase are necessary for collagen binding in corneal epithelia: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) → PIP2/Gelsolin complex (GSN) (actin filament polymerization, collaborate)
  
• BioCarta integrin signaling pathway: None → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) (modification, collaborate)
  
• BioCarta integrin signaling pathway: Zyxin (ZYX) → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) (modification, collaborate)
  
• BioCarta integrin signaling pathway: CSK → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) (modification, collaborate)
  
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1) → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) (modification, collaborate)
  
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1) → alpha-actinin (ACTN3/ACTN2/ACTN1/ACTN4) (modification, collaborate)
  
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) → Tensin (TNS1) (modification, collaborate)
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) → FAK (PTK2) (modification, collaborate)
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) → NOLC1 (modification, collaborate)
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) → Calpain1 (CAPN1) (modification, collaborate)
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) → Actin (ACTA1) (modification, collaborate)
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) → alpha-actinin (ACTN3/ACTN2/ACTN1/ACTN4) (modification, collaborate)
  
• BioCarta erk and pi-3 kinase are necessary for collagen binding in corneal epithelia: Rho-Kinase Dia/Profilin complex (PFN1-DIAPH1) → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin (active1)/p130cas/FAK/CSK/Paxillin/Vinculin/alp complex (ITGA1-PTK2-BCAR1-ACTN3_ACTN2_ACTN1_ACTN4-ZYX-TLN1-ITGB1-VCL-PXN-CSK-ACTA1-TNS1-CAPN1) (actin filament polymerization, activates)
  
• BioCarta erk and pi-3 kinase are necessary for collagen binding in corneal epithelia: Rho-Kinase Dia/Profilin complex (PFN1-DIAPH1) → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) (actin filament polymerization, activates)
  
• BioCarta erk and pi-3 kinase are necessary for collagen binding in corneal epithelia: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin (active1)/p130cas/FAK/CSK/Paxillin/Vinculin/alp complex (ITGA1-PTK2-BCAR1-ACTN3_ACTN2_ACTN1_ACTN4-ZYX-TLN1-ITGB1-VCL-PXN-CSK-ACTA1-TNS1-CAPN1) → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) (actin filament polymerization, collaborate)
  
• BioCarta ucalpain and friends in cell spread: RAC1 → Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2) (modification, activates)
  
• BioCarta ucalpain and friends in cell spread: Talin (TLN1) → Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2) (modification, collaborate)
  
• BioCarta ucalpain and friends in cell spread: Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2) → Integrin-alpha/Integrin-beta/ECM complex (ITGA1-ITGB1) (modification, collaborate)
  
• BioCarta ucalpain and friends in cell spread: Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2) → FODRIN (SPTAN1) (modification, collaborate)
• BioCarta ucalpain and friends in cell spread: Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2) → Actin (ACTA1) (modification, collaborate)
• BioCarta ucalpain and friends in cell spread: Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2) → Ezrin (VIL2) (modification, collaborate)
• BioCarta ucalpain and friends in cell spread: Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2) → alpha-actinin (ACTN3/ACTN2/ACTN1/ACTN4) (modification, collaborate)
  
• BioCarta ucalpain and friends in cell spread: Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2) → PAX (PXN) (modification, collaborate)
• BioCarta ucalpain and friends in cell spread: alpha-actinin (ACTN3/ACTN2/ACTN1/ACTN4) → PAX (PXN) (modification, collaborate)
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin (active1)/p130cas/FAK/CSK/Paxillin/Vinculin/alp complex (ITGA1-PTK2-BCAR1-ACTN3_ACTN2_ACTN1_ACTN4-ZYX-TLN1-ITGB1-VCL-PXN-CSK-ACTA1-TNS1-CAPN1) → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) (actin filament polymerization, collaborate)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• MIPS CORUM Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1): Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1) complex (ACTN1-BCAR1-CDH1-CTNNB1-JUP-PKD1-PTK2-PXN-SRC-TLN1-VCL) Geng et al., Biochim Biophys Acta 2000
• IRef Corum Interaction: Complex of 12 proteins (association, cosedimentation through density gradient) Geng et al., Biochim Biophys Acta 2000