Schönbeck et al., Circulation 2002
(Coronary Stenosis) :
Platelet enriched plasma of mice deficient in CD40L showed markedly delayed fibrin clot formation, suggesting a role for the ligand in blood coagulation and supporting the hypothesis that statin mediated reduction in CD40/CD40L expression might limit thrombosis
Pignatelli et al., Journal of thrombosis and haemostasis : JTH 2007
(Hypercholesterolemia) :
We speculated that in patients with hypercholesterolemia CD40L overexpression could depend on low-density lipoprotein (LDL) induced enhanced intraplatelet formation of O ( 2 ) * ( - ) and statin could reduce platelet CD40L via interference with platelet O ( 2 ) * ( - ) production