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CHUK — TP53

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: TP53 — CHUK (in vivo) Mao et al., Proc Natl Acad Sci U S A 2002*
• IRef Ophid Interaction: CHUK — TP53 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Fujioka et al., J Biol Chem 2004 : Importantly, lack of RelA, IKK , and p53 as well as expression of a dominant negative IkappaBalpha ( IkappaBalphaM ) inhibited NF-kappaB dependent p53 activation and apoptosis
Gu et al., J Biol Chem 2004 : Furthermore, ETS-1 mediated activation of IKKalpha is negatively regulated by p53 binding to ETS-1 ... Induction or enforced overexpression of p53 represses IKKalpha mRNA and protein expression as well as IKKalpha promoter activity
Furuya et al., J Biol Chem 2007 : Here, we show for the first time that p73, but not p53 , is stabilized by physical interaction with nuclear IkappaB kinase (IKK)-alpha to enhance cisplatin ( CDDP ) -induced apoptosis
Yamaguchi et al., J Biol Chem 2007 : Importantly, the ectopic expression of IKKalpha into cells silenced for USP11 restores p53 expression, demonstrating that USP11 functions as an upstream regulator of an IKKalpha-p53 signaling pathway
Rasmussen et al., Inflamm Res 2008 (Inflammation) : An IkappaB kinase 2 inhibitor, sc514, also strongly reduced IL-8 and significantly induced p53 protein levels
Jia et al., Cell Death Differ 2013 : IKK-ß and p85 S6K1 contributed to H ( 2 ) O ( 2 ) -induced phosphorylation of Mdm2 ( S166 ) and p53 accumulation