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Kawauchi et al., J Biol Chem 2002
:
In the transient expression assay, ATF3 suppressed the p53 gene promoter activity through its specific binding to an atypical AP-1 element, PF-1 site, in the p53 gene promoter
Yoshida et al., J Am Soc Nephrol 2008
(Acute Kidney Injury...) :
In conclusion, ATF3 plays a protective role in renal ischemia-reperfusion injury and the mechanism of the protection may involve suppression of p53 and induction of p21
Blancafort et al., Mol Cancer Ther 2008
:
Small interfering RNA mediated inhibition of p53 revealed that 3ZF-1-VP activated both p53 dependent and p53 independent mechanisms to promote survival, whereas other ATF required intact p53