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CD46 — IL10
Text-mined interactions from Literome
Olszyna et al., J Infect Dis 2000
(Endotoxemia) :
Sixteen healthy subjects were intravenously injected with lipopolysaccharide (LPS), once with placebo and once with recombinant human interleukin (IL)-10 ( 25 microgram/kg ), to determine the
effect of
IL-10 on LPS induced production of macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and
monocyte chemoattractant protein (MCP)-1
Marie et al., Nat Immunol 2002
(Dermatitis, Contact...) :
We found that engagement of
CD46-1 or CD46-2 differentially
affected CD8 ( + ) T cell cytotoxicity, CD4 ( + ) T cell proliferation,
interleukin 2 (IL-2) and IL-10 production as well as tyrosine phosphorylation of Vav in T lymphocytes
Sánchez et al., Eur J Immunol 2004
:
The
effect of
CD46 on
IL-10 secretion did not require additional costimuli like anti-CD28 antibodies or phorbol esters
Jones et al., J Immunol 2009
:
Neither the genetic absence of IL-4, IL-4Ralpha chain, STAT-6, IFN-gamma, or IL-12p40 nor mAb blockade of IFN-gamma, IL-3, IL-4, IL-5, IL-6,
IL-10 , IL-13, IL-17A, IL-12p40, or IL-12p40Rbeta1 before Ag challenge in WT mice
reduces the pulmonary
MCp increase
Bayraktar et al., Am J Reprod Immunol 2009
:
Interestingly,
IL-10 down-regulated LTA mediated
MCP1 induction, but not that mediated by LPS
Su et al., Clinical and vaccine immunology : CVI 2010
(Tuberculosis, Pulmonary) :
The levels of expression of TNF-alpha,
MCP-1 , IFN-gamma, and IL-1beta were decreased ; and the level of
IL-10 increased in early responders
Cardone et al., Clin Exp Immunol 2011
(Immune Complex Diseases) :
However, in the last 10 years, it has become apparent that
CD46 is also heavily
involved in a new and somewhat surprising functional aspect of the complement system : the down-modulation of adaptive T helper type 1 ( Th1 ) immune responses by regulating the production of interferon ( IFN ) -? versus
interleukin (IL)-10 within these cells