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HGF — IL10
Text-mined interactions from Literome
Matsumoto et al., Biochem Biophys Res Commun 1992
:
Up-regulation of
hepatocyte growth factor gene expression by
interleukin-1 in human skin fibroblasts
Takami et al., Biochem Biophys Res Commun 2004
:
HGF production is
induced by the activation of protein kinase A and protein kinase C-mediated pathways,
interleukin (IL)-1 , tumor necrosis factor (TNF)-alpha, and epidermal growth factor (EGF) in mesenchymal cells
Futamatsu et al., Circ Res 2005
(Autoimmune Diseases...) :
HGF suppressed T cell proliferation and production of IFN-gamma and increased production of IL-4 and
IL-10 secreted from CD4 positive T cells in vitro
Knowles et al., Clin Cancer Res 2009
(Carcinoma, Squamous Cell...) :
c-Met TKIs blocked
HGF induced signaling,
interleukin-8 release, and wound healing
Lan et al., Zhonghua Gan Zang Bing Za Zhi 2009
(Disease Models, Animal...) :
The expression of
HGF and PCNA was further
increased by BDLSCs or
IL-10 modified BDLSCs transplantation
Schmeding et al., Transplantation 2010
(Fatty Liver) :
Analysis of liver enzymes, histology ( hematoxylin-eosin and periodic acid Schiff stain ), immunostaining ( terminal deoxynucleotide transferase- mediated dUTP nick-end labeling, hypoxyprobe, and tumor necrosis factor-alpha ), and reverse transcriptase-polymerase chain reaction of cytokine messenger RNA (
interleukin-1 , interleukin-6, hypoxia
induced factor-1 alpha, vascular endothelial growth factor, and
hepatocyte growth factor ) were performed at defined time points ( 2, 4.5, 24, 48 hr, and 7 days postoperatively )
Chen et al., Stem Cells Dev 2011
(Acute Kidney Injury...) :
Real-time polymerase chain reaction result showed that
HGF-hucMSCs also
inhibited caspase-3 and
interleukin-1ß mRNA expression in injured renal tissues
Shintani et al., Atherosclerosis 2011
(Aortic Aneurysm, Abdominal) :
In ex vivo cultures of human AAA tissue, exogenously added
HGF in the presence of tumor necrosis factor-alpha ( TNF-a )
enhanced the secretion of anti-inflammatory cytokine
interleukin-10 (IL-10) and suppressed the secretion of proinflammatory monocyte/macrophage chemotactic protein-1 (MCP-1)
Singhal et al., J Biol Chem 2011
:
Blocking activation of Btk and its downstream the c-Src-PI3K-AKT-mTOR pathway prevents
HGF induced
IL-10 secretion by DCs
Wang et al., Hum Gene Ther 2013
(Disease Models, Animal...) :
MSCs-HGF could reduce secretion and expression of proinflammatory cytokines, including tumor necrosis factor-a, interferon-?, interleukin (IL)-6, and intercellular adhesion molecule-1, and
increase the expression of antiinflammatory cytokine
IL-10 ...
MSCs-HGF could
reduce secretion and expression of proinflammatory cytokines, including tumor necrosis factor-a, interferon-?,
interleukin (IL)-6, and intercellular adhesion molecule-1, and increase the expression of antiinflammatory cytokine IL-10
Bazin et al., J Immunol 1987
(Ascites...) :
The
HGF activity was not
mediated by
interleukin 1 because the two activities could be completely separated by gel filtration
Sugiyama et al., Infect Immun 1996
:
Lipoteichoic acid and
interleukin 1
stimulate synergistically production of
hepatocyte growth factor ( scatter factor ) in human gingival fibroblasts in culture
Gohda et al., J Cell Physiol 1998
(Leukemia) :
Granulocyte colony stimulating factor ( G-CSF ), granulocyte/macrophage colony stimulating factor ( GM-CSF ),
interleukin (IL)-5 and IL-6
had no effect on
HGF/SF production in the 2 leukemia cell lines
Bamba et al., Biochem Biophys Res Commun 1998
(Peptic Ulcer...) :
Among various potential stimulants tested,
interleukin-1 beta (IL-1 beta) dramatically increased PGE2 production and significantly
stimulated HGF production
Miyazaki et al., Biochem Biophys Res Commun 1998
:
Increased
hepatocyte growth factor production by aging human fibroblasts mainly
due to autocrine stimulation by
interleukin-1 ... The increased production of
HGF by aging fibroblasts from human embryonic lung tissue is mainly
due to autocrine stimulation by
interleukin-1