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MMP9 — PI3

Text-mined interactions from Literome

Haruyama et al., Biochem Biophys Res Commun 2000 : The increased expression of MMP-9 by the cytokines was inhibited by cytochalasin D or colchicine but not by PI3 kinase inhibitor wortmannin
Estève et al., Biochem Biophys Res Commun 2002 : Here, we report that PI 3-kinase inhibits MMP-9 expression induced by either IL-1 or TNF-alpha in rat C6 glioma cells
Price et al., Cell communication & adhesion 2002 (Breast Neoplasms...) : In response to EGF, T4-2 cells showed a 5-fold greater secretion of matrix metalloproteinase-9 (MMP-9) as compared to S-1 cells, and this increase was largely dependent on the activity of PI 3-kinase
Zou et al., FASEB J 2008 (Disease Progression...) : Furthermore, phosphatidylinositol 3-kinase (PI3K) inhibitors could suppress beta-Arr1 enhanced MMP9 activity and the C-terminal 181-418 amino acids ( aa ) of beta-Arr1 was largely responsible for this effect
Kim et al., Neurochem Int 2010 (Parkinson Disease) : Treatment with several signaling pathway-specific inhibitors revealed that the PI3 kinase inhibitor, LY294002, suppressed 6-OHDA- and MPP ( + ) -induced MMP-9 promoter activities, whereas the p38 MAPK inhibitor, SB203580, inhibited 6-OHDA-, but not MPP ( + ) -induced promoter activity
Furundzija et al., Biochem Biophys Res Commun 2010 (Atherosclerosis) : This involves activation of integrins and focal adhesion formation via inside-out PI3-kinase/PKC/p38 dependent signaling, but does not require MMP activation
Yen et al., J Biol Chem 2011 (MAP Kinase Signaling System) : PKA, PI3K , and ERK inhibitors abolished PGE2- and cAMP induced c-Fos and MMP-9 up-regulation, and ERK activation was required for the binding of activator protein 1 (AP-1) transcription factor to the MMP-9 promoter
Yoo et al., Cancer Res 2011 (Lymphatic Metastasis...) : Mechanistic investigations revealed that phosphoinositide 3-kinase (PI3K)/Akt inhibition blocked Shh induced epithelial-mesenchyme transition, the activity of matrix metalloproteinase 9 (MMP-9) , and lymphangiogenesis, reducing tumor invasiveness and metastasis
Dilly et al., Int J Cancer 2013 (Neoplasm Invasiveness...) : Specific inhibitors of 12-LOX, PI3K or NF-?B inhibited MMP9 expression in 12-LOX expressing PC-3 cells and resulted in the blockade of the migratory ability of endothelial cells