Zhang et al., J Biol Chem 2001
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Cyclin a-CDK phosphorylation regulates MDM2 protein interactions
Giono et al., Mol Cell Biol 2007
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Mdm2 is required for inhibition of Cdk2 activity by p21, thereby contributing to p53 dependent cell cycle arrest
Zhang et al., J Biol Chem 2008
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Thus, CDK inhibitors suppress MDM2 levels and enhance p53 expression that facilitates bile acid induced, ceramide dependent CD95 activation to induce both apoptosis and autophagy in primary hepatocytes