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P2RY6 — PTGS2

Text-mined interactions from Literome

Takai et al., Radiat Res 2011 (Inflammation) : Involvement of P2Y6 receptor in p38 MAPK mediated COX-2 expression in response to UVB irradiation of human keratinocytes ... Our results indicate that UVB radiation evokes ATP release from human keratinocytes and also that activation of P2Y6 receptor mediates the UVB-radiation induced activation of p38 MAPK and expression of COX-2
Ishida et al., Am J Physiol Heart Circ Physiol 2011 (Diabetes Mellitus, Type 2...) : In arteries from GK rats ( vs. those from Wistar rats ), 1 ) ATP- and UTP induced contractions, which were blocked by the nonselective P2 antagonist suramin, were enhanced, and these enhancements were suppressed by endothelial denudation, by cyclooxygenase (COX) inhibitors, or by a cytosolic phospholipase A ( 2 ) ( cPLA(2) ) inhibitor ; 2 ) both nucleotides induced increased release of PGE ( 2 ) and PGF ( 2a ) ; 3 ) nucleotide stimulated cPLA(2) phosphorylations were increased ; 4 ) COX-1 and COX-2 expressions were increased ; and 5 ) neither P2Y2 nor P2Y6 receptor expression differed, but P2Y4 receptor expression was decreased