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IL6 — MMP9

Text-mined interactions from Literome

Meisser et al., Mol Hum Reprod 1999 : The aim of this study was to determine the effects of tumour necrosis factor alpha (TNF), interleukin-1 alpha (IL-1alpha), macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases ( MMP ) , human chorionic gonadotrophin ( HCG ) and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro
Kossakowska et al., Blood 1999 (Lymphoma, Non-Hodgkin...) : Moreover, in human lymphoid cell lines of B- and T-cell origin ( Raji, Jurkat, and NC-37 ), IL-6 stimulated production of MMP-9 and MMP-2 but not TIMP-1
Shlopov et al., J Rheumatol 2001 (Osteoarthritis) : A decrease in IL-1alpha, IL-1beta, and IL-6 would reduce stimulation of MMP production, while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves
Carstanjen et al., Transfusion 2002 : In contrast, IL-6 might be involved in the G-CSF induced expression of MMP-9
Imafuku et al., Clin Chim Acta 2002 : We also found a definite effects on copper, angiotensin converting enzyme (ACE), matrix metalloproteinase (MMP)-1 , -3 and -9, tissue inhibitor of matrix metalloproteinase ( TIMP ) -1, hepatocyte growth factor (HGF), monoamine oxidase ( MAO ), vitamin B ( 12 ), ACTH and IL-6 , though the mechanisms were not clear
Hirata et al., Biol Reprod 2003 : Membrane type-1 MMP mRNA expression in the stromal cells was augmented by tumor necrosis factor alpha (TNFalpha), IL-6 , HGF, and 12-O-tetradecanoylphorbol 13-acetate
Sun et al., Connect Tissue Res 2003 (Arthritis, Rheumatoid) : Furthermore, the induction of the MMP expression and activities by interleukin-1 was suppressed by the oscillatory shear
Legendre et al., J Rheumatol 2005 (MAP Kinase Signaling System) : IL-6/sIL-6R markedly induced activation of STAT and extracellular signal related kinase ( ERK1/2 ) and the subsequent expression of the collagenases MMP-1 and MMP-13 as well as MMP-3, an aggrecan degrading enzyme and activator of pro-MMP
Chen et al., Ann Neurol 2006 (Intracranial Arteriovenous Malformations) : IL-6 induced MMP-3 and MMP-9 expression and activity in mouse brain and increased proliferation and migration of cerebral endothelial cells
Yao et al., Biochem Biophys Res Commun 2006 : Using human cerebral endothelial cell ( HCEC ), we report for the first time that IL-6 triggers HCEC proliferation and migration in a dose dependent manner, specifically associated with enhancement of VEGF expression, up-regulated and phosphorylated VEGF receptor-2 ( KDR ), and stimulated MMP-9 secretion ... We conclude that IL-6 triggers VEGF induced angiogenic activity through increasing VEGF release, up-regulates KDR expression and phosphorylation through activating ERK1/2 signaling, and stimulates MMP-9 overexpression
Giannelli et al., J Interferon Cytokine Res 2006 : In this study, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), commonly elevated in chronic C hepatitis, stimulate the production of matrix metalloprotease-9 (MMP-9) by human hepatocytes at a transcriptional and translational level, but the addition of recombinant interferon-alpha2b ( rIFN-alpha2b ) hampers this effect
Yao et al., J Cereb Blood Flow Metab 2007 (Arteriovenous Malformations) : Interleukin-6 could increase matrix metalloproteinase-9 (MMP-9) secretion through activating KDR in control HCSMCs ( P < 0.05 versus control ) ... Inhibiting IL-6 induced KDR could reduce MMP-9 activity at least 50 % compared with the control group ( P < 0.05 )
Previti et al., Journal of neuroinflammation 2006 : Our results suggest that although dexamethasone has no appreciable consequence on HCSM cell surface fibrillar Abeta accumulation it effectively reduces the subsequent pathologic responses including elevated levels of IL-6 , MMP-2 activation , and depletion of HCSM alpha actin
Kundu et al., J Biol Chem 2006 (Helicobacter Infections) : In addition, increased secretion of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6 induced pro-MMP-9 secretion and synthesis in AM1 or SS1 strain infected mice suggesting elicitation of pro-inflammatory cytokines by both cag- and cag+ genotype
Ju et al., Exp Mol Med 2009 (AIDS Dementia Complex...) : Furthermore, HIV-1 Tat induced expression of MMP-9 was significantly inhibited by neutralization of TNF-alpha, but not IL-1beta and IL-6
Min et al., American journal of physiology. Renal physiology 2009 (Diabetes Mellitus, Experimental...) : These cytokines all increased adhesion and differentiation of THP1 cells ( P < 0.05 ), but only TNF-alpha and IL-6 increased MMP-9 expression ( 50- and 60-fold, respectively ; P < 0.05 )
Li et al., J Cell Biochem 2010 (MAP Kinase Signaling System) : Although it is known that interleukin (IL)-6 is a key proinflamatory cytokine, it remains unclear how IL-6 regulates MMP expression by mononuclear phagocytes ... Furthermore, it remains undetermined how IL-6 in combination with hyperglycemia affects MMP expression
Sakata et al., Circ J 2010 (Fever...) : Interleukin (IL)-1beta, IL-6 , and tumor necrosis factor (TNF)-alpha stimulated MMP-9 expression, whereas interferon (IFN)-gamma suppressed it
Chew et al., BMC cancer 2010 (Nasopharyngeal Neoplasms...) : We conclude that IL-6 reduced cell adherence towards laminin and increased MMP-9 production in NPC cells
Butoi et al., Biochim Biophys Acta 2011 : Silencing the p65 ( NF-kB subunit ) inhibited the IL-1ß and IL-6 and silencing c-jun inhibited the TNFa, CX3CR1 and MMP-9 induced by SMC-monocyte interaction
Wang et al., Phytomedicine 2011 : 200 nM MMP-9 CD stimulated cardiac fibroblasts migration ( 169.4±22.5 % versus 100±0 %, p < 0.01 ), increased collagen synthesis ( 1.5±0.2 fold, p < 0.05 ), up-regulated the secretion of ICAM ( 574.0±40.1 versus 268.5±8.6pg/ml, p < 0.01 ), TNF-a ( 192.6±11.0 versus 14.4±1.8pg/ml, p < 0.001 ), IL-6 ( 1500.9±70.2 versus 323.4±40.6pg/ml, p < 0.001 ) and sVCAM-1 ( 30.3±4.3 versus 7.0±0.1 pg/ml, p < 0.05 ) and down-regulated VEGF ( 436.5±148.9 versus 1034.3±28.1 pg/ml, p < 0.05 ) significantly with modest effects on proliferation
Mann et al., Ann Otol Rhinol Laryngol 1995 (Carcinoma, Squamous Cell...) : Supernatants of HNSCC cell lines SCC-25 and FADU stimulated with interleukin (IL)-1 alpha and IL-1 beta demonstrated modest induction of 92 kd GL production by zymogram analysis when compared with controls ; IL-2, IL-6 , and interferon-gamma had no consistent effect on MMP production
Richards et al., J Immunol 1993 (Neoplasms) : The results suggest that OM as well as IL-6 and LIF, other cytokines acting through similar receptor pathways, may act to inhibit net MMP activity by specifically up-regulating TIMP-1 expression
Alexander et al., Curr Eye Res 1998 : A phorbol mitogen ( TPA ), and TNF alpha and beta, interleukin-1 alpha and PDGF BB stimulate gelatinase B , stromelysin, interstitial collagenase and TIMP-1 expression, while having negligible effects on gelatinase A expression ; TIMP-2 levels are reduced by TNF but not affected by the other treatments