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EGFR — IFI27
Text-mined interactions from Literome
Sheng et al., Mol Biol Cell 2005
:
Futhermore, the V1 isoform was able to not only activate proto-oncogene
EGFR expression and modulate its downstream signaling pathway, but also
induce p27 degradation and enhance CDK2 kinase activity
Langner et al., BJU Int 2005
(Carcinoma, Renal Cell...) :
During progression to category pT1b, expression of
p27 significantly decreased ( 54 % ) and
EGFR expression
increased ( 38 % )
Santra et al., J Cereb Blood Flow Metab 2006
(Glioma) :
Blocking of phosphoinositide 3-kinase (PI-3K), Ras, and the
epidermal growth factor receptor with specific inhibitors
had no effect on induction of Ras, p21, and
p27 at the messenger RNA level in decorin synthesizing SVZ and U-87 cells
Calvo et al., Ann Oncol 2007
(Carcinoma, Squamous Cell...) :
Nevertheless, erlotinib inhibited
p-EGFR in HNSCC tumors, which appeared associated to clinical benefit, and
induced p27 in biopsies of normal skin