Valente et al., Free Radic Biol Med 2013
:
Advanced oxidation protein products induce cardiomyocyte death via Nox2/Rac1/superoxide dependent TRAF3IP2/JNK signaling ... AOPP-MSA stimulated Nox2/Rac1 dependent superoxide generation, TRAF3IP2 expression, and TRAF3IP2 dependent JNK activation ... AOPP-MSA stimulated Nox2/Rac1 dependent superoxide generation, TRAF3IP2 expression, and TRAF3IP2 dependent JNK activation ... These results demonstrate for the first time that AOPPs induce cardiomyocyte death via Nox2/Rac1/superoxide dependent TRAF3IP2/JNK activation in vitro and suggest that AOPPs may contribute to myocardial injury in vivo
Valente et al., Cell Signal 2013
:
IL-18 induced Nox1 dependent ROS generation, TRAF3IP2 expression, and IKK/NF-?B and JNK/AP-1 activation