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FZD8 — WNT1

Pathways - manually collected, often from reviews:

• KEGG Wnt signaling pathway: WNT1/WNT10A/WNT10B/WNT11/WNT16/WNT2/WNT2B/WNT3/WNT3A/WNT4/WNT5A/WNT5B/WNT6/WNT7A/WNT7B/WNT8A/WNT8B/WNT9A/WNT9B → FZD1/FZD10/FZD2/FZD3/FZD4/FZD5/FZD6/FZD7/FZD8/FZD9 (protein-protein, activation)
  
• KEGG Melanogenesis: WNT1/WNT10A/WNT10B/WNT11/WNT16/WNT2/WNT2B/WNT3/WNT3A/WNT4/WNT5A/WNT5B/WNT6/WNT7A/WNT7B/WNT8A/WNT8B/WNT9A/WNT9B → FZD1/FZD10/FZD2/FZD3/FZD4/FZD5/FZD6/FZD7/FZD8/FZD9 (protein-protein, activation)
  
• KEGG Pathways in cancer: WNT1/WNT10A/WNT10B/WNT11/WNT16/WNT2/WNT2B/WNT3/WNT3A/WNT4/WNT5A/WNT5B/WNT6/WNT7A/WNT7B/WNT8A/WNT8B/WNT9A/WNT9B → FZD1/FZD10/FZD2/FZD3/FZD4/FZD5/FZD6/FZD7/FZD8/FZD9 (protein-protein, activation)
  
• KEGG Basal cell carcinoma: WNT1/WNT10A/WNT10B/WNT11/WNT16/WNT2/WNT2B/WNT3/WNT3A/WNT4/WNT5A/WNT5B/WNT6/WNT7A/WNT7B/WNT8A/WNT8B/WNT9A/WNT9B → FZD1/FZD10/FZD2/FZD3/FZD4/FZD5/FZD6/FZD7/FZD8/FZD9 (protein-protein, activation)
  
• NCI Pathway Database Wnt signaling network: WNT1/FZD8/LRP6 complex (WNT1-FZD8-LRP6) → LRP6/DKK1 complex (DKK1-LRP6) (modification, collaborate)
  Tamai et al., Nature 2000, Mao et al., Nature 2001, Semënov et al., Curr Biol 2001, Binnerts et al., Mol Biol Cell 2009*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Wnt signaling network: WNT1/FZD8/LRP6 complex (WNT1-FZD8-LRP6) → DKK1 (DKK1) (modification, collaborate) Tamai et al., Nature 2000, Mao et al., Nature 2001, Semënov et al., Curr Biol 2001, Binnerts et al., Mol Biol Cell 2009*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Wnt signaling network: WNT1/FZD8/LRP6 complex (WNT1-FZD8-LRP6) → LRP6 (LRP6) (modification, collaborate) Tamai et al., Nature 2000, Mao et al., Nature 2001, Semënov et al., Curr Biol 2001, Binnerts et al., Mol Biol Cell 2009*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Wnt signaling network: WNT1/FZD8/LRP6 complex (WNT1-FZD8-LRP6) → FZD8 (FZD8) (modification, collaborate) Tamai et al., Nature 2000, Mao et al., Nature 2001, Semënov et al., Curr Biol 2001, Binnerts et al., Mol Biol Cell 2009*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Wnt signaling network: WNT1/FZD8/LRP6 complex (WNT1-FZD8-LRP6) → WNT1 (WNT1) (modification, collaborate) Tamai et al., Nature 2000, Mao et al., Nature 2001, Semënov et al., Curr Biol 2001, Binnerts et al., Mol Biol Cell 2009*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Wnt signaling network: FZD8 (FZD8) → WNT1 (WNT1) (modification, collaborate) Tamai et al., Nature 2000, Mao et al., Nature 2001, Semënov et al., Curr Biol 2001, Binnerts et al., Mol Biol Cell 2009*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Wnt signaling network: WNT1/FZD8/Ryk complex (WNT1-FZD8-RYK) → WNT1 (WNT1) (modification, collaborate) Lu et al., Cell 2004*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Wnt signaling network: WNT1/FZD8/Ryk complex (WNT1-FZD8-RYK) → Ryk (RYK) (modification, collaborate) Lu et al., Cell 2004*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Wnt signaling network: WNT1/FZD8/Ryk complex (WNT1-FZD8-RYK) → FZD8 (FZD8) (modification, collaborate) Lu et al., Cell 2004*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Wnt signaling network: WNT1 (WNT1) → FZD8 (FZD8) (modification, collaborate) Lu et al., Cell 2004*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Wnt signaling network: LRP6 (LRP6) → WNT1/FZD8/LRP6 complex (WNT1-FZD8-LRP6) (modification, collaborate)
  Semënov et al., J Biol Chem 2005*, Ellies et al., J Bone Miner Res 2006*, Collette et al., Dev Biol 2010*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Wnt signaling network: WNT1/FZD8/LRP6 complex (WNT1-FZD8-LRP6) → WNT1 (WNT1) (modification, collaborate) Semënov et al., J Biol Chem 2005*, Ellies et al., J Bone Miner Res 2006*, Collette et al., Dev Biol 2010*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Wnt signaling network: WNT1/FZD8/LRP6 complex (WNT1-FZD8-LRP6) → LRP6/FZD8/SOST complex (LRP6-FZD8) (modification, collaborate)
  Semënov et al., J Biol Chem 2005*, Ellies et al., J Bone Miner Res 2006*, Collette et al., Dev Biol 2010*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Wnt signaling network: WNT1/FZD8/LRP6 complex (WNT1-FZD8-LRP6) → FZD8 (FZD8) (modification, collaborate) Semënov et al., J Biol Chem 2005*, Ellies et al., J Bone Miner Res 2006*, Collette et al., Dev Biol 2010*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Wnt signaling network: WNT1 (WNT1) → LRP6/FZD8/SOST complex (LRP6-FZD8) (modification, collaborate)
  Semënov et al., J Biol Chem 2005*, Ellies et al., J Bone Miner Res 2006*, Collette et al., Dev Biol 2010*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Wnt signaling network: WNT1 (WNT1) → FZD8 (FZD8) (modification, collaborate) Semënov et al., J Biol Chem 2005*, Ellies et al., J Bone Miner Res 2006*, Collette et al., Dev Biol 2010*
  Evidence: mutant phenotype, physical interaction
• Reactome Reaction: FZD8 → WNT1 (reaction) Hsieh et al., Proc Natl Acad Sci U S A 1999, Mikels et al., PLoS Biol 2006
• Reactome Reaction: FZD8 → WNT1 (direct_complex) Hsieh et al., Proc Natl Acad Sci U S A 1999, Mikels et al., PLoS Biol 2006
• WikiPathways ESC Pluripotency Pathways: WNT3/WNT5B/WNT7A/WNT5A/WNT16/WNT10A/WNT7B/WNT2/WNT9B/WNT3A/WNT11/WNT4/WNT1/WNT6/WNT10B/WNT2B → Complex of 12 proteins (activation)
• WikiPathways Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds: FZD8/DKK3/SFRP4/FZD7 → WNT1 (mim-inhibition)
• WikiPathways Wnt Signaling Pathway and Pluripotency: WNT9B/WNT4/WNT7B/WNT10B/WNT5B/WNT2B/WNT3A/WNT16/WNT7A/WNT2/WNT11/WNT1/WNT6/WNT5A/WNT10A/WNT3 → FZD8/FZD7/FZD5/FZD1/FZD6/FZD3/FZD2/FZD10/FZD9/FZD4 (activation)
  
• WikiPathways Wnt Signaling in Kidney Disease: WNT1/WNT10A/WNT10B/WNT7A/WNT16/WNT6/WNT5A/WNT2B/WNT11/WNT4/WNT3A/WNT5B/WNT9B/WNT2/WNT3/WNT7B → FZD1/FZD8/FZD4/FZD2/FZD7/FZD9/FZD5/FZD6/FZD3 (activation)
  
• WikiPathways Wnt Signaling in Kidney Disease: WNT1/WNT10A/WNT10B/WNT7A/WNT16/WNT6/WNT5A/WNT2B/WNT11/WNT4/WNT3A/WNT5B/WNT9B/WNT2/WNT3/WNT7B → LRP5/LRP6/FZD1/FZD8/FZD4/FZD2/FZD7/FZD9/FZD5/FZD6/FZD3 (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: WNT1 — FZD8 Lu et al., Cell 2004*
• IRef Bind Interaction: Complex of WNT1-RYK-FZD8 Lu et al., Cell 2004*
• IRef Bind_translation Interaction: WNT1 — FZD8 (coimmunoprecipitation) Lu et al., Cell 2004*
• IRef Biogrid Interaction: WNT1 — FZD8 (physical association, affinity chromatography technology) Semënov et al., Curr Biol 2001
• IRef Hprd Interaction: WNT1 — FZD8 (in vivo) Lu et al., Cell 2004*

Text-mined interactions from Literome

Castelo-Branco et al., Proc Natl Acad Sci U S A 2003 : Moreover, the soluble cysteine-rich domain of Frizzled-8 ( a Wnt inhibitor ) blocked endogenous Wnts and the effects of Wnt-1 and -5a on proliferation and the acquisition of a DA phenotype in precursor cultures
Albers et al., J Cell Biol 2013 (Bone Resorption...) : These results demonstrate that Fzd8 and ß-catenin negatively regulate osteoclast differentiation independent of osteoblasts and that canonical Wnt signaling controls bone resorption by two different mechanisms
Yin et al., Mol Cancer Ther 2013 (Breast Neoplasms) : Taken together, our findings suggest that FZD8 mediated Wnt signaling may play a major role in mediating resistance to chemotherapy, making it a potential target to enhance chemotherapeutic efficacy in patients with TNBCs. Mol Cancer Ther ; 12 ( 4 ) ; 491-8