Gene interactions and pathways from curated databases and text-mining

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CARD10 — CASP8

Text-mined interactions from Literome

Zhou et al., Proc Natl Acad Sci U S A 1999 : Direct recruitment and activation of caspase-9 by Apaf-1 through the homophilic CARD/CARD ( Caspase Recruitment Domain ) interaction is critical for the activation of caspases downstream of mitochondrial damage in apoptosis
Shiozaki et al., Proc Natl Acad Sci U S A 2002 : Oligomerization and activation of caspase-9 , induced by Apaf-1 CARD
Chamaillard et al., Cell Microbiol 2003 (Bacterial Infections...) : NBS-LRR proteins are characterized by three structural domains : a C-terminal leucine-rich repeat ( LRR ) domain able to sense a microbial motif, an intermediary nucleotide binding site (NBS) essential for the oligomerization of the molecule that is necessary for the signal transduction induced by different N-terminal effector motifs, such as a pyrin domain ( PYD ), a caspase activating and recruitment domain ( CARD ) or a baculovirus inhibitor of apoptosis protein repeat ( BIR ) domain