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Wang et al., J Am Soc Nephrol 1999 : Activation of NFkappaB by delipidated bovine serum albumin ( 15 mg/ml ) was detectable within 2 h, maximal after 8 h, and maintained for at least 16 h of continuous exposure ... Therefore, albumin increased NFkappaB and reduced IkappaB levels in PTC, and MCP-1 expression was dependent on NFkappaB activation
Cantin et al., Am J Respir Crit Care Med 2000 : We conclude that albumin specifically modulates cellular GSH levels, an effect sufficient to protect cells against oxidant injury and regulate NF-kappaB activation
Drumm et al., Eur J Med Res 2001 (Albuminuria) : We investigated albumin induced NF-kappaB activation and the potential contribution of tyrosine kinase and protein kinase C ... Therefore we exposed proximal tubule derived human ( IHKE-1 ), opossum ( OK ) and porcine ( LLC-PK1 ) cell lines to serum albumin at concentrations of 10 - 500 mg/l. DNA binding activity of NF-kappaB increased concentration-dependently in the presence of albumin ... The albumin induced increase in NF-kappaB DNA binding activity was inhibited by herbimycin A ( tyrosine kinase inhibitor ) and BIM ( protein kinase C inhibitor )
Drumm et al., Cell Physiol Biochem 2002 : The aim of this study was to investigate albumin induced NF-kappaB expression as well as NF-kappaB activity upon long long term exposure to albumin in human proximal tubular cells as only acute albumin induced NF-kappaB activity has been reported so far ... An albumin induced increase in TNF-alpha specific mRNA expression as biological, inflammatory parameter associated with the albumin induced NF-kappaB activity was detectable
Morcos et al., Diabetes 2002 (Diabetes Mellitus, Type 2...) : The findings that excreted pTECs demonstrate activated NF-kappaB and IL-6 antigen and that AGE-albumin and CML lead to a perpetuated activation of NF-kappaB in vitro infer that a perpetuated increase in proinflammtory gene products, such as IL-6, plays a role in damaging the renal tubule
Wang et al., J Surg Res 2004 : The present studies were performed to identify whether the reduction of albumin expression induced by LPS was mediated by activating nuclear factor kappa B(NF-kappaB) in cultured rat hepatocytes ... The results suggest that LPS inhibits albumin expression by activating NF-kappaB signaling
Reich et al., J Am Soc Nephrol 2005 : One pathway involves the activation of NFkappaB by albumin , and it has been demonstrated that the activation of NFkappaB induced by albumin is dependent on mitogen activated protein kinase ERK1/ERK2
Rodríguez-Ayala et al., Atherosclerosis 2005 (Inflammation...) : In the patient group with high-grade inflammation, stimulation of mononuclear cells with CML modified human serum albumin caused a rapid dose dependent rise ( p < 0.0001 ) in NFkappaB activity that could be completely blocked by an anti-RAGE antibody
Mahaseth et al., J Lab Clin Med 2005 (Anemia, Sickle Cell...) : Control albumin had no effect on NF-kappaB , VCAM-1, ICAM-1, rolling, adhesion, or vasoocclusion
Tang et al., J Am Soc Nephrol 2006 (Diabetic Nephropathies...) : Also in a dose dependent manner, GA ( 0.5 mg/ml ) but not albumin caused nuclear translocation of NF-kappaB and activation of mitogen activated protein kinase ( MAPK ) p44/p42 and signal transducer and activator of transcription ( STAT-1 )
Harada et al., Diabetes Res Clin Pract 2006 (Diabetic Retinopathy...) : In vitro studies demonstrated that glycated albumin or high glucose induces NF-kappaB activation followed by up-regulation of MCP-1 promoter activity and protein production in glial cells
Li et al., American journal of physiology. Renal physiology 2010 : Furthermore, glycated albumin increased nuclear NF-kappaB subunit-p65 protein levels
Yan et al., J Biol Chem 1994 (Diabetes Mellitus) : AGE albumin or AGEs immunoisolated from diabetic plasma resulted in induction of endothelial cell ( EC ) oxidant stress, including the generation of thiobarbituric acid reactive substances ( TBARS ) and resulted in the activation of NF-kappa B , each of which was blocked by antibodies to AGE receptor polypeptides and by antioxidants
Bierhaus et al., Circulation 1997 : Electrophoretic mobility shift assays and Western blot analysis demonstrated that the AGE albumin induced translocation of NF-kappaB from the cytoplasm into the nucleus was suppressed in the presence of antisense RAGE but not by sense RAGE