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CTNNB1 — PIN1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Ryo et al., Nat Cell Biol 2001
(Adenomatous Polyposis Coli) :
A differential-display screen reveals that
Pin1 increases the transcription of several
beta-catenin target genes, including those encoding cyclin D1 and c-Myc ... Thus,
Pin1 is a novel regulator of beta-catenin signalling and its overexpression might
contribute to the upregulation of
beta-catenin in tumours such as breast cancer, in which APC or beta-catenin mutations are not common
Ryo et al., J Cell Sci 2003
(Neoplasms) :
Pin1 regulates the expression of cyclin D1 by cooperating with Ras signaling and inhibiting the interaction of
beta-catenin with the tumor suppressor APC and also directly stabilizing cyclin D1 protein
Miyashita et al., Oncol Rep 2003
(Carcinoma, Squamous Cell...) :
A differential-display screen reveals that
Pin1 increases the transcription of several
beta-catenin target genes, including those encoding cyclin D1 and c-Myc
Pang et al., Oncogene 2004
(Carcinoma, Hepatocellular) :
The
role of
PIN1 in
beta-catenin upregulation in HCC was investigated
Nakashima et al., J Pathol 2004
(Cell Transformation, Neoplastic...) :
This study aimed to elucidate whether
Pin1 was
involved in cyclin D1 overexpression and aberrant
beta-catenin in thyroid tumourigenesis by examining 14 follicular adenomas (FAa) and 14 papillary thyroid carcinomas ( PTCs )
Kim et al., World J Gastroenterol 2005
(Colorectal Neoplasms...) :
Overexpression of Pin1 and beta-catenin may be closely related with the development and/or progression of colorectal carcinoma and further supports that
Pin1 overexpression might
contribute to the upregulation of
beta-catenin
Chen et al., Mol Cell Biol 2006
(Neoplasm Metastasis...) :
Pin1 expression in LNCaP cells
enhanced beta-catenin/Tcf4 transcriptional activity, as assessed using Tcf4 regulated reporter genes, and increased expression of endogenous Tcf4 and c-myc ... However, in contrast to results in cells with intact PTEN and active GSK-3beta,
Pin1 expression in LNCaP PCa cells, which are PTEN deficient, did not
increase beta-catenin ... Instead,
Pin1 expression markedly
inhibited the
beta-catenin interaction with AR, and Pin1 abrogated the ability of AR to antagonize beta-catenin/Tcf4 binding and transcriptional activity ... These findings demonstrate that AR can suppress beta-catenin signaling, that the AR-beta-catenin interaction can be regulated by
Pin1 , and that abrogation of this interaction can
enhance beta-catenin/Tcf4 signaling and contribute to aggressive biological behavior in PCa
Zhou et al., Oncol Rep 2006
(Carcinoma, Adenoid Cystic...) :
The aims of this study were to investigate the expression levels of beta-catenin, Pin1 and cyclin D1 in salivary adenoid cystic carcinomas ( SACC ) and to evaluate its clinical importance, furthermore, to elucidate whether
beta-catenin expression was aberrant in SACC and whether
Pin1 was
involved in aberrant beta-catenin and cyclin D1 expression
Kim et al., APMIS 2006
(Disease Progression...) :
The
effect of
Pin1 on
beta-catenin expression was further examined in wild- and mutant-type Pin1 transfected HEK 293T cells