Gene interactions and pathways from curated databases and text-mining

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PTPN1 — SIRT1

Text-mined interactions from Literome

Sun et al., Cell Metab 2007 (Insulin Resistance) : Further studies demonstrated that the effect of SIRT1 on insulin resistance is mediated by repressing PTP1B transcription at the chromatin level
Gagarina et al., Arthritis Rheum 2010 (Osteoarthritis) : Activation of IGFR occurs at least in part via SirT1 mediated repression of PTP1B